Structure−Activity Relationships of N  2-Aryl-3-(isoxazolylsulfamoyl)-2-thiophenecarboxamides as Selective Endothelin Receptor-A Antagonists

We report here that N  2-aryl-3-(isoxazolylsulfamoyl)-2-thiophenecarboxamides are potent and selective small molecule ETA receptor antagonists. The aryl group was subjected to extensive structural modification. With monosubstitution, the para position was most useful in increasing potency, with meth...

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Veröffentlicht in:	Journal of medicinal chemistry 1997-05, Vol.40 (11), p.1682-1689
Hauptverfasser:	Wu, Chengde, Chan, Ming F, Stavros, Fiona, Raju, B, Okun, Ilya, Castillo, Rosario S
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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