Structure−Activity Relationships for a Series of Quinoline-Based Compounds Active against Replicating and Nonreplicating Mycobacterium tuberculosis

Tuberculosis (TB) remains as a global pandemic that is aggravated by a lack of health care, the spread of HIV, and the emergence of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) strains. New anti-TB drugs are urgently required to shorten the long 6−12 month treatment reg...

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Veröffentlicht in:	Journal of medicinal chemistry 2009-04, Vol.52 (7), p.2109-2118
Hauptverfasser:	Lilienkampf, Annamaria, Mao, Jialin, Wan, Baojie, Wang, Yuehong, Franzblau, Scott G, Kozikowski, Alan P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents - chemical synthesis Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Biological and medical sciences Cercopithecus aethiops Drug Resistance, Bacterial Drug Resistance, Multiple, Bacterial Isoxazoles - chemical synthesis Isoxazoles - chemistry Isoxazoles - pharmacology Medical sciences Microbial Sensitivity Tests Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - physiology Pharmacology. Drug treatments Quinolines - chemical synthesis Quinolines - chemistry Quinolines - pharmacology Structure-Activity Relationship Vero Cells
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