Nuclear Factor-κB Mediated Inhibition of Cytokine Production by Imidazoline Scaffolds

The mammalian nuclear transcription factor NF-κB is responsible for the transcription of multiple cytokines, including the pro-inflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6). Elevated levels of pro-inflammatory cytokines play an important role in the pathogenesis...

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Veröffentlicht in:	Journal of medicinal chemistry 2009-03, Vol.52 (5), p.1302-1309
Hauptverfasser:	Kahlon, Daljinder K, Lansdell, Theresa A, Fisk, Jason S, Hupp, Christopher D, Friebe, Timothy L, Hovde, Stacy, Jones, A. Daniel, Dyer, Richard D, Henry, R. William, Tepe, Jetze J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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