Structure of Daidzin, a Naturally Occurring Anti-Alcohol-Addiction Agent, in Complex with Human Mitochondrial Aldehyde Dehydrogenase

The ALDH2*2 gene encoding the inactive variant form of mitochondrial aldehyde dehydrogenase (ALDH2) protects nearly all carriers of this gene from alcoholism. Inhibition of ALDH2 has hence become a possible strategy to treat alcoholism. The natural product 7-O-glucosyl-4′-hydroxyisoflavone (daidzin)...

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Veröffentlicht in:	Journal of medicinal chemistry 2008-08, Vol.51 (15), p.4482-4487
Hauptverfasser:	Lowe, Edward D, Gao, Guang-Yao, Johnson, Louise N, Keung, Wing Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcoholism - enzymology Alcoholism and acute alcohol poisoning Aldehyde Dehydrogenase - antagonists & inhibitors Aldehyde Dehydrogenase - metabolism Aldehyde Dehydrogenase, Mitochondrial Animals Behavior, Addictive - enzymology Binding Sites Biological and medical sciences Cricetinae Crystallography, X-Ray Humans Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Isoflavones - chemistry Isoflavones - pharmacology Medical sciences Mitochondria - drug effects Mitochondria - enzymology Models, Molecular Molecular Structure Retinal Dehydrogenase Structure-Activity Relationship Toxicology
Online-Zugang:	Volltext
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