Amino Acid Modified Xanthone Derivatives: Novel, Highly Promising Membrane-Active Antimicrobials for Multidrug-Resistant Gram-Positive Bacterial Infections

Antibiotic resistance is a critical global health care crisis requiring urgent action to develop more effective antibiotics. Utilizing the hydrophobic scaffold of xanthone, we identified three components that mimicked the action of an antimicrobial cationic peptide to produce membrane-targeting anti...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 2015-01, Vol.58 (2), p.739-752
Hauptverfasser:	Koh, Jun-Jie, Lin, Shuimu, Aung, Thet Tun, Lim, Fanghui, Zou, Hanxun, Bai, Yang, Li, Jianguo, Lin, Huifen, Pang, Li Mei, Koh, Wee Luan, Salleh, Shuhaida Mohamed, Lakshminarayanan, Rajamani, Zhou, Lei, Qiu, Shengxiang, Pervushin, Konstantin, Verma, Chandra, Tan, Donald T. H, Cao, Derong, Liu, Shouping, Beuerman, Roger W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - pharmacology Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Cell Membrane - drug effects Drug Resistance, Multiple, Bacterial Gram-Positive Bacterial Infections - drug therapy Magnetic Resonance Spectroscopy Mice Microbial Sensitivity Tests Rabbits Structure-Activity Relationship Unilamellar Liposomes Xanthones - chemical synthesis Xanthones - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!