Conjugation of a Nonspecific Antiviral Sapogenin with a Specific HIV Fusion Inhibitor: A Promising Strategy for Discovering New Antiviral Therapeutics

Triterpene saponins are a major group of active components in natural products with nonspecific antiviral activities, while T20 peptide (enfuvirtide), which contains a helix zone-binding domain (HBD), is a gp41-specific HIV-1 fusion inhibitor. In this paper, we report the design, synthesis, and stru...

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Veröffentlicht in:	Journal of medicinal chemistry 2014-09, Vol.57 (17), p.7342-7354
Hauptverfasser:	Wang, Chao, Lu, Lu, Na, Heya, Li, Xiangpeng, Wang, Qian, Jiang, Xifeng, Xu, Xiaoyu, Yu, Fei, Zhang, Tianhong, Li, Jinglai, Zhang, Zhenqing, Zheng, Baohua, Liang, Guodong, Cai, Lifeng, Jiang, Shibo, Liu, Keliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Cell Line Cell Line, Tumor Cell Survival - drug effects HIV Envelope Protein gp41 - chemistry HIV Envelope Protein gp41 - genetics HIV Envelope Protein gp41 - pharmacology HIV Fusion Inhibitors - chemistry HIV Fusion Inhibitors - pharmacology HIV-1 - drug effects Humans Models, Chemical Models, Molecular Molecular Sequence Data Molecular Structure Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - pharmacology Protein Structure, Secondary Sapogenins - chemistry Sapogenins - pharmacology Structure-Activity Relationship
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