Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease

A series of multitarget-directed resveratrol derivatives was designed and synthesized for the treatment of Alzheimer’s disease (AD). In vitro studies indicated that most of the target compounds exhibit significant inhibition of self-induced β-amyloid (Aβ) aggregation and Cu(II)-induced Aβ1–42 aggre...

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Veröffentlicht in:	Journal of medicinal chemistry 2013-07, Vol.56 (14), p.5843-5859
Hauptverfasser:	Lu, Chuanjun, Guo, Yueyan, Yan, Jun, Luo, Zonghua, Luo, Hai-Bin, Yan, Ming, Huang, Ling, Li, Xingshu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - chemistry Animals Antioxidants - chemical synthesis Antioxidants - therapeutic use Blood-Brain Barrier Cholinesterase Inhibitors - chemical synthesis Clioquinol - analogs & derivatives Drug Design Humans Mice Monoamine Oxidase Inhibitors - chemical synthesis Peptide Fragments - antagonists & inhibitors Peptide Fragments - chemistry Stilbenes - chemistry Stilbenes - therapeutic use
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