Phosphoramidate ProTides of 2′-C-Methylguanosine as Highly Potent Inhibitors of Hepatitis C Virus. Study of Their in Vitro and in Vivo Properties

Hepatitis C virus infection constitutes a serious health problem in need of more effective therapies. Nucleoside analogues with improved exposure, efficacy, and selectivity are recognized as likely key components of future HCV therapy. 2′-C-Methylguanosine triphosphate has been known as a potent inh...

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Veröffentlicht in:	Journal of medicinal chemistry 2010-07, Vol.53 (13), p.4949-4957
Hauptverfasser:	McGuigan, Christopher, Gilles, Arnaud, Madela, Karolina, Aljarah, Mohamed, Holl, Sabrina, Jones, Sarah, Vernachio, John, Hutchins, Jeff, Ames, Brenda, Bryant, K. Dawn, Gorovits, Elena, Ganguly, Babita, Hunley, Damound, Hall, Andrea, Kolykhalov, Alexander, Liu, Yule, Muhammad, Jerry, Raja, Nicholas, Walters, Robin, Wang, Jin, Chamberlain, Stanley, Henson, Geoffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analysis Amides - chemical synthesis Amides - chemistry Amides - pharmacology Animals Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Cell Line Female Guanosine - analogs & derivatives Guanosine - chemical synthesis Guanosine - chemistry Guanosine - pharmacology Hepacivirus - physiology Hepatitis C - drug therapy Hepatitis C - virology Humans Liver - metabolism Liver - virology Magnetic Resonance Spectroscopy Mice Mice, Inbred ICR Phosphoric Acids - chemical synthesis Phosphoric Acids - chemistry Phosphoric Acids - pharmacology Virus Replication - drug effects
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