Synthesis and in Vitro Antiprotozoal Activity of Bisbenzofuran Cations

Forty three cationic bisbenzofurans were synthesized either by interaction of o-hydroxyaldehydes with α-halogenated ketones followed by intramolecular ring closure or by a copper- or palladium-mediated heteroannulation of substituted o-iodophenols with terminal acetylenes. In vitro antiprotozoal act...

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Veröffentlicht in:	Journal of medicinal chemistry 2007-11, Vol.50 (23), p.5807-5823
Hauptverfasser:	Bakunova, Svetlana M, Bakunov, Stanislav A, Wenzler, Tanja, Barszcz, Todd, Werbovetz, Karl A, Brun, Reto, Hall, James Edwin, Tidwell, Richard R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - chemical synthesis Antimalarials - pharmacology Antimalarials - toxicity Antiparasitic agents Benzofurans - chemical synthesis Benzofurans - pharmacology Benzofurans - toxicity Biological and medical sciences Cations Leishmania donovani - drug effects Medical sciences Pharmacology. Drug treatments Plasmodium falciparum - drug effects Rats Structure-Activity Relationship Trypanocidal Agents - chemical synthesis Trypanocidal Agents - pharmacology Trypanocidal Agents - toxicity Trypanosoma brucei rhodesiense - drug effects
Online-Zugang:	Volltext
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