In Vivo Anti-Chagas Vinylthio-, Vinylsulfinyl-, and Vinylsulfonylbenzofuroxan Derivatives

New benzofuroxans were developed and studied as antiproliferative Trypanosoma cruzi agents. Compounds displayed remarkable in vitro activities against different strains, Tulahuen 2, CL Brener and Y. Its unspecific cytotoxicity was evaluated using human macrophages being not toxic at a concentration...

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Veröffentlicht in:	Journal of medicinal chemistry 2007-11, Vol.50 (24), p.6004-6015
Hauptverfasser:	Porcal, Williams, Hernández, Paola, Boiani, Mariana, Aguirre, Gabriela, Boiani, Lucía, Chidichimo, Agustina, Cazzulo, Juan J, Campillo, Nuria E, Paez, Juan A, Castro, Ana, Krauth-Siegel, R. Luise, Davies, Carolina, Basombrío, Miguel Ángel, González, Mercedes, Cerecetto, Hugo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies, Protozoan - blood Antiparasitic agents Benzoxazoles - chemical synthesis Benzoxazoles - pharmacology Benzoxazoles - toxicity Biological and medical sciences Cell Line Chagas Disease - drug therapy Cysteine Endopeptidases - metabolism Female Glutathione - metabolism Humans Macrophages - drug effects Medical sciences Mice Models, Molecular NADH, NADPH Oxidoreductases - metabolism Oxidation-Reduction Oxygen Consumption - drug effects Pharmacology. Drug treatments Stereoisomerism Structure-Activity Relationship Sulfones - chemical synthesis Sulfones - chemistry Sulfones - pharmacology Trypanocidal Agents - chemical synthesis Trypanocidal Agents - pharmacology Trypanocidal Agents - toxicity Trypanosoma cruzi - drug effects Trypanosoma cruzi - enzymology Trypanosoma cruzi - physiology Vinyl Compounds - chemical synthesis Vinyl Compounds - chemistry Vinyl Compounds - pharmacology
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