Antidiabetic Activity of Passive Nonsteroidal Glucocorticoid Receptor Modulators

Much has been learned about the consequences of glucocorticoid receptor antagonism by studying steroidal active antagonists such as RU-38486 (1). In the liver glucocorticoid receptor antagonism suppresses hepatic glucose production decreasing plasma glucose levels; however, extrahepatic antagonism p...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 2005-08, Vol.48 (16), p.5295-5304
Hauptverfasser:	Link, J. T, Sorensen, Bryan, Patel, Jyoti, Grynfarb, Marlena, Goos-Nilsson, Annika, Wang, Jiahong, Fung, Steven, Wilcox, Denise, Zinker, Brad, Nguyen, Phong, Hickman, Bach, Schmidt, James M, Swanson, Sue, Tian, Zhenping, Reisch, Thomas J, Rotert, Gary, Du, Jia, Lane, Benjamin, von Geldern, Thomas W, Jacobson, Peer B
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - biosynthesis Alkaline Phosphatase - genetics Animals Benzylamines - adverse effects Benzylamines - chemical synthesis Benzylamines - pharmacology Biological and medical sciences Cells, Cultured Cricetinae Cricetulus Dexamethasone - pharmacology Female General and cellular metabolism. Vitamins Genes, Reporter Glucocorticoids - pharmacology Hepatocytes - drug effects Hepatocytes - enzymology Humans Hypoglycemic Agents - adverse effects Hypoglycemic Agents - chemical synthesis Hypoglycemic Agents - pharmacology Hypothalamo-Hypophyseal System - drug effects Male Medical sciences Mice Pharmacology. Drug treatments Pituitary-Adrenal System - drug effects Pregnancy Radioligand Assay Rats Rats, Sprague-Dawley Receptors, Glucocorticoid - antagonists & inhibitors Receptors, Glucocorticoid - genetics Sulfonamides - adverse effects Sulfonamides - chemical synthesis Sulfonamides - pharmacology Transcriptional Activation - drug effects Tyrosine Transaminase - biosynthesis Uterus - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!