Conformationally Restricted Analogues of Psorospermin: Design, Synthesis, and Bioactivity of Natural-Product-Related Bisfuranoxanthones

The antileukemic xanthone psorospermin is a topoisomerase II−dependent DNA alkylator in advanced preclinical development. Efforts have been made to further understand the structural requirements of its mechanism of action through the synthesis of ring-constrained analogues, based on the skeleton of...

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Veröffentlicht in:	Journal of medicinal chemistry 2005-04, Vol.48 (8), p.2993-3004
Hauptverfasser:	Heald, Robert A, Dexheimer, Thomas S, Vankayalapati, Hariprasad, Siddiqui-Jain, Adam, Szabo, Lajos Z, Gleason-Guzman, Mary C, Hurley, Laurence H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents, Alkylating - chemical synthesis Antineoplastic Agents, Alkylating - chemistry Antineoplastic Agents, Alkylating - pharmacology Biological and medical sciences Cell Line, Tumor DNA Topoisomerases, Type II - metabolism Drug Design Drug Screening Assays, Antitumor Furans - chemical synthesis Furans - chemistry Furans - pharmacology General aspects Humans Medical sciences Models, Molecular Molecular Conformation Pharmacology. Drug treatments Stereoisomerism Structure-Activity Relationship Xanthones - chemical synthesis Xanthones - chemistry Xanthones - pharmacology
Online-Zugang:	Volltext
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