A Novel Approach of Water-Soluble Paclitaxel Prodrug with No Auxiliary and No Byproduct: Design and Synthesis of Isotaxel

A novel water-soluble paclitaxel prodrug, isotaxel 2, that realizes a higher water-solubility and the formation of paclitaxel through a simple pH-dependent chemical mechanism via the O−N acyl migration was synthesized and showed promising results in water-solubility and kinetics. This prodrug, a 2‘-...

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Veröffentlicht in:	Journal of medicinal chemistry 2003-08, Vol.46 (18), p.3782-3784
Hauptverfasser:	Hayashi, Yoshio, Skwarczynski, Mariusz, Hamada, Yoshio, Sohma, Youhei, Kimura, Tooru, Kiso, Yoshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Biological and medical sciences General aspects Hydrogen-Ion Concentration Kinetics Medical sciences Paclitaxel - administration & dosage Paclitaxel - analogs & derivatives Paclitaxel - chemical synthesis Paclitaxel - chemistry Pharmacology. Drug treatments Prodrugs - chemical synthesis Prodrugs - chemistry Solubility Water
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