Synthesis of Urea-Based Inhibitors as Active Site Probes of Glutamate Carboxypeptidase II:  Efficacy as Analgesic Agents

The neuropeptidase glutamate carboxypeptidase II (GCPII) hydrolyzes N-acetyl-l-aspartyl-l-glutamate (NAAG) to liberate N-acetylaspartate and glutamate. GCPII was originally cloned as PSMA, an M r 100 000 type II transmembrane glycoprotein highly expressed in prostate tissues. PSMA/GCPII is located o...

Ausführliche Beschreibung