3-(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)- N-alkyl-N-arylbenzamides:  Potent, Non-Peptidic Agonists of Both the μ and δ Opioid Receptors

Opioid analgesics with both μ and δ opioid receptor activation represent a new approach to the treatment of severe pain with an improved safety profile. Compounds with this profile may exhibit strong analgesic properties due to μ agonism, with a reduced side effect profile resulting from δ agonism....

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Veröffentlicht in:	Journal of medicinal chemistry 2003-02, Vol.46 (4), p.623-633
Hauptverfasser:	Bishop, Michael J, Garrido, Dulce M, Boswell, G. Evan, Collins, Mark A, Harris, Philip A, McNutt, Robert W, O'Neill, Scott J, Wei, Ke, Chang, Kwen-Jen
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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