Design and Synthesis of 4-Substituted Benzamides as Potent, Selective, and Orally Bioavailable I Ks Blockers

Multiple delayed rectifier potassium currents, including I Ks, are responsible for the repolarization and termination of the cardiac action potential, and blockers of these currents may be useful as antiarrhythmic agents. Modification of compound 5 produced 19(S) that is the most potent I Ks blocker...

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Veröffentlicht in:	Journal of medicinal chemistry 2001-11, Vol.44 (23), p.3764-3767
Hauptverfasser:	Lloyd, John, Schmidt, Joan B, Rovnyak, George, Ahmad, Saleem, Atwal, Karnail S, Bisaha, Sharon N, Doweyko, Lidia M, Stein, Philip D, Traeger, Sarah C, Mathur, Arvind, Conder, Mary Lee, DiMarco, John, Harper, Timothy W, Jenkins-West, Tonya, Levesque, Paul C, Normandin, Diane E, Russell, Anita D, Serafino, Randolph P, Smith, Mark A, Lodge, Nicholas J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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