Selective Activation of Mitomycin A by Thiols To Form DNA Cross-links and Monoadducts: Biochemical Basis for the Modulation of Mitomycin Cytotoxicity by the Quinone Redox Potential

Mitomycin A (MA) but not mitomycin C (MC) cross-linked linearized 32P-pBR322 DNA in the presence of dithiothreitol (DTT) or glutathione (GSH), as shown by a sensitive DNA cross-link assay. Incubation of calf-thymus DNA with MA and DTT or mercaptoethanol (MER) resulted in the formation of MA−DNA addu...

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Veröffentlicht in:	Journal of medicinal chemistry 2001-08, Vol.44 (17), p.2834-2842
Hauptverfasser:	Paz, Manuel M, Das, Arunangshu, Palom, Yolanda, He, Qiao-Yun, Tomasz, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonium Hydroxide Animals Antibiotics, Antineoplastic - chemistry Antineoplastic agents Antineoplastic Agents, Alkylating - chemistry Benzoquinones - chemistry Biological and medical sciences Cattle Chromatography, High Pressure Liquid Cross-Linking Reagents - chemistry Dithiothreitol - chemistry DNA - chemistry DNA Adducts - chemistry General aspects Hydroxides - chemistry Medical sciences Mitomycin - chemistry Mitomycins - chemistry Oligodeoxyribonucleotides - chemistry Oxidation-Reduction Pharmacology. Drug treatments Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Ultraviolet Sulfhydryl Compounds - chemistry
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