Ergolines as selective 5-HT1 agonists

The synthesis and serotonin receptor subtype affinity of a series of ergolines are described. High selectivity for the 5-HT1 subtype was found with a number of 8-substituted (3 beta, 5 beta)-9,10-didehydro-6-methylergolines. The more potent and selective of these compounds increased the concentratio...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1988-08, Vol.31 (8), p.1512-1519
Hauptverfasser:	Ward, John S, Fuller, Ray W, Merritt, Leander, Snoddy, Harold D, Paschal, Jonathan W, Mason, Norman R, Horng, J. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apomorphine - pharmacology Brain - drug effects Brain - metabolism Chemical Phenomena Chemistry Corticosterone - blood Drug Interactions Ergolines - chemical synthesis Ergolines - pharmacology Exact sciences and technology Fenclonine - pharmacology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Hydroxyindoleacetic Acid - metabolism Organic chemistry Preparations and properties Rats Receptors, Serotonin - drug effects Serotonin - metabolism Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!