A simplified high-pressure liquid chromatography method for determining lipophilicity for structure-activity relationships

A highly deactivated octadecyl-bonded silica column and a mobile phase consisting of an water-methanol mixture in the range of blood pH and ionic strength are used to correlate log kappa' with biological activity for a series of sulfonamides and barbiturates. The results were compared to litera...

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Veröffentlicht in:	Journal of medicinal chemistry 1983-07, Vol.26 (7), p.1014-1020
Hauptverfasser:	Brent, David A, Sabatka, Julie J, Minick, Douglas J, Henry, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria - drug effects Barbiturates - pharmacology Biological Assay Cell Division - drug effects Chromatography, High Pressure Liquid - methods Female Ovum - drug effects Oxygen Consumption - drug effects Rabbits Solubility Structure-Activity Relationship Sulfanilamides - toxicity
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