Intracyclization rates of 6-hydroxydopamine and 6-aminodopamine analogs under physiological conditions

It is agreed that the neurotoxic action of 6-hydroxydopamine and 6-aminodopamine is related to their ease of oxidation. The initial oxidation products, the p-quinone and p-quinone imine, readily undergo 1,2-intracyclization. These reactions could represent an important loss of active neurotoxic agen...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 1976-01, Vol.19 (1), p.178-180
Hauptverfasser:	Blank, C. L, McCreery, Richard L, Wightman, R. M, Chey, W, Adams, Ralph N, Reid, J. R, Smissman, Edward E
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Phenomena Chemistry Cyclization Dopamine - analogs & derivatives Dopamine - metabolism Half-Life Hydroxydopamines - metabolism Neurons - metabolism Oxidation-Reduction Potentiometry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!