Synthesis and antihypertensive activity of novel 3-hydrazino-5-phenyl-1,2,4-triazines

In an effort to develop antihypertensive agents with peripheral vasodilator activity, a series of 40 novel 3-hydrazino-5-phenyl-1,2,4-triazines (II) were synthesized and evaluated in the spontaneously hypertensive rat assay (SHR assay). Based on the performance of the structurally related standard,...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 1979-06, Vol.22 (6), p.671-677
Hauptverfasser:	Heilman, William P, Heilman, Richard D, Scozzie, James A, Wayner, Robert J, Gullo, James M, Ariyan, Zaven S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - chemical synthesis Blood Pressure - drug effects Dose-Response Relationship, Drug Heart Rate - drug effects Hypertension - physiopathology Lethal Dose 50 Male Mice Rats Structure-Activity Relationship Triazines - chemical synthesis Triazines - pharmacology Triazines - toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!