4-Substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogs as potential antimalarial agents

Five 4-substituted 5-[m-(trifluoromethyl)phenoxy]primaquine analogues were synthesized and tested for radical curative activity against Plasmodium cynomolgi in Rhesus monkeys and for blood schizonticidal antimalarial activity against Plasmodium berghei in mice. In addition, they were evaluated for c...

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Veröffentlicht in:	Journal of medicinal chemistry 1985-11, Vol.28 (11), p.1564-1567
Hauptverfasser:	Carroll, F. Ivy, Berrang, Bertold, Linn, C. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemical Phenomena Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Macaca mulatta Malaria - drug therapy Mice Organic chemistry Plasmodium Preparations and properties Primaquine - analogs & derivatives Primaquine - chemical synthesis Primaquine - therapeutic use Structure-Activity Relationship
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