Synthesis and ocular antihypertensive activity of new imidazolidine derivatives containing a .beta.-blocking side chain

The syntheses of new phenylimidazolidine derivatives (3-6)1 containing a propanolamine oxime or an oxypropanolamine moiety attached either to the aromatic or to the imidazolidine ring are described. These compounds were evaluated for potential ocular antihypertensive activity in alpha-chymotrypsin-i...

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Veröffentlicht in:	Journal of medicinal chemistry 1991-11, Vol.34 (11), p.3197-3204
Hauptverfasser:	Huber, D, Ehrhardt, J. D, Decker, N, Himber, J, Andermann, G, Leclerc, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - chemical synthesis Antihypertensive Agents - therapeutic use Chemistry Exact sciences and technology Glaucoma - chemically induced Glaucoma - drug therapy Guinea Pigs Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Hypertension - drug therapy Imidazoles - chemical synthesis Imidazoles - therapeutic use Male Muscle, Smooth - drug effects Muscle, Smooth, Vascular - drug effects Organic chemistry Preparations and properties Rabbits Rats Receptors, Adrenergic - drug effects Structure-Activity Relationship
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