Synthesis and biological activity of D3-trishomocubyl-4-amines

The D3-trishomocubyl system was prepared from tertiary pentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecan-8-ols 5 in one step by using a modified Ritter reaction yielding only one of the possible two geometrical isomers of 4-amino-3-alkyl (or aryl)-D3-trishomocubane (8). Promising antagonism of reserpin...

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Veröffentlicht in:	Journal of medicinal chemistry 1991-02, Vol.34 (2), p.851-854
Hauptverfasser:	Oliver, Douglas W, Dekker, Theodor G, Snyckers, Friedrich O, Fourie, Theunis G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiparkinson Agents - chemical synthesis Antiparkinson Agents - therapeutic use Antiparkinson Agents - toxicity Bridged-Ring Compounds - chemical synthesis Bridged-Ring Compounds - therapeutic use Bridged-Ring Compounds - toxicity Catalepsy - drug therapy Chemical Phenomena Chemistry Male Mice Stereoisomerism Structure-Activity Relationship
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