4,5-Dihydro-1-phenyl-1H-2,4-benzodiazepines: Novel antiarrhythmic agents

A series of 4,5-dihydro-1-phenyl-1H-2,4-benzodiazepines has been identified as potential antiarrhythmic agents that interact with sodium and potassium channels and prolong the ventricular effective refractory period (ERP) in anesthetized guinea pigs. Concomitant displacement of radiolabeled bactrach...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1993-10, Vol.36 (22), p.3361-3370
Hauptverfasser:	Johnson, Robert E, Baizman, Eugene R, Becker, Carolyn, Bohnet, Eric A, Bell, Rebecca H, Birsner, Nancy C, Busacca, Carl A, Carabateas, Philip M, Chadwick, Christopher C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Arrhythmia Agents - chemical synthesis Anti-Arrhythmia Agents - pharmacology Antiarythmic agents Arrhythmias, Cardiac - drug therapy Benzodiazepines - chemical synthesis Benzodiazepines - pharmacology Biological and medical sciences Cardiovascular system Cats Disease Models, Animal Dogs Guinea Pigs Heart Ventricles - drug effects Male Medical sciences Myocardial Contraction - drug effects Myocardial Contraction - physiology Myocardial Infarction - drug therapy Pharmacology. Drug treatments Potassium Channels - drug effects Potassium Channels - physiology Rats Rats, Sprague-Dawley Refractory Period, Electrophysiological - drug effects Sodium Channels - drug effects Sodium Channels - physiology Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!