Antiinflammatory 4,5-Diarylpyrroles: Synthesis and QSAR

A series of 2-substituted- and 2,3-disubstituted-4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-1H- pyrroles was synthesized and found to be active in the rat adjuvant arthritis model of inflammation. The most active compounds were the 2-halo derivatives in the order of chloro > bromo > iodo....

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Veröffentlicht in:	Journal of medicinal chemistry 1994-04, Vol.37 (7), p.988-998
Hauptverfasser:	Wilkerson, Wendell W, Galbraith, William, Gans-Brangs, Kathleen, Grubb, Mary, Hewes, Walter E, Jaffee, Bruce, Kenney, J. P, Kerr, Janet, Wong, Nancy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Anti-Inflammatory Agents, Non-Steroidal - toxicity Arthritis, Experimental - drug therapy Chemistry Disease Models, Animal Drug Tolerance Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Male Organic chemistry Preparations and properties Pyrroles - chemical synthesis Pyrroles - pharmacokinetics Pyrroles - therapeutic use Pyrroles - toxicity Rats Rats, Sprague-Dawley Structure-Activity Relationship
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