Symmetrical Bis(heteroarylmethoxyphenyl)alkylcarboxylic Acids as Inhibitors of Leukotriene Biosynthesis

Symmetrical bis(quinolylmethoxyphenyl)alkylcarboxylic acids were investigated as inhibitors of leukotriene biosynthesis and 4,4-bis(4-(2-quinolylmethoxy)phenyl)pentanoic acid sodium salt (47·Na) met our design parameters for a drug candidate (ABT-080). This compound was readily synthesized in three...

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Veröffentlicht in:	Journal of medicinal chemistry 2000-08, Vol.43 (17), p.3322-3334
Hauptverfasser:	Kolasa, Teodozyj, Gunn, David E, Bhatia, Pramila, Basha, Anwer, Craig, Richard A, Stewart, Andrew O, Bouska, Jennifer B, Harris, Richard R, Hulkower, Keren I, Malo, Peter E, Bell, Randy L, Carter, George W, Brooks, Clint D. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Anaphylaxis - metabolism Animals Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology Bronchoconstriction - drug effects Carboxylic Acids - chemical synthesis Carboxylic Acids - chemistry Carboxylic Acids - pharmacokinetics Carboxylic Acids - pharmacology Drug Evaluation, Preclinical Eosinophils - pathology Guinea Pigs Humans In Vitro Techniques Leukotriene Antagonists - chemical synthesis Leukotriene Antagonists - chemistry Leukotriene Antagonists - pharmacokinetics Leukotriene Antagonists - pharmacology Leukotriene B4 - antagonists & inhibitors Leukotriene B4 - biosynthesis Lung - pathology Macaca fascicularis Medical sciences Mice Neutrophils - metabolism Pentanoic Acids - chemical synthesis Pentanoic Acids - chemistry Pentanoic Acids - pharmacokinetics Pentanoic Acids - pharmacology Peritoneum - metabolism Pharmacology. Drug treatments Pleurisy - chemically induced Pleurisy - drug therapy Quinolines - chemical synthesis Quinolines - chemistry Quinolines - pharmacokinetics Quinolines - pharmacology Rats Respiratory system Structure-Activity Relationship
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