Bisimidazoacridones and Related Compounds: New Antineoplastic Agents with High Selectivity against Colon Tumors

A new class of potent and highly selective antitumor agents has been synthesized. Bisimidazoacridones, where the tetracyclic ring systems are held together by either a N2-methyldiethylenetriamine or 3,3'-diamino-N-methyldipropylamine linker, and related asymmetrical compounds, where one of the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1995-08, Vol.38 (16), p.3043-3052
Hauptverfasser:	Cholody, Wieslaw M, Hernandez, Lidia, Hassner, Lawrence, Scudiero, Dominic A, Djurickovic, Draginja B, Michejda, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacridines - chemistry Aminoacridines - pharmacology Animals Antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Base Sequence Biological and medical sciences Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Computer Graphics DNA - drug effects Drug Screening Assays, Antitumor General aspects Humans Male Medical sciences Mice Mice, Nude Molecular Sequence Data Neoplasm Transplantation Pharmacology. Drug treatments Structure-Activity Relationship Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!