Substituted (1,2-Diarylethyl)amide Acyl-CoA:Cholesterol Acyltransferase Inhibitors: Effect of Polar Groups on in Vitro and in Vivo Activity

Substituted (1,2-diarylethyl)amides have been prepared and evaluated for their ability to inhibit microsomal acyl-CoA:cholesterol acyltransferase activity in vitro and to lower hepatic cholesteryl ester content in vivo in a cholesterol-fed hamster. Simple unsubstituted (diarylethyl)amides were poten...

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Veröffentlicht in:	Journal of medicinal chemistry 1995-05, Vol.38 (10), p.1600-1607
Hauptverfasser:	Clader, John W, Berger, Joel G, Burrier, Robert E, Davis, Harry R, Domalski, Martin, Dugar, Sundeep, Kogan, Timothy P, Salisbury, Brian, Vaccaro, Wayne
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Amides - pharmacology Animals Anticholesteremic Agents - chemistry Anticholesteremic Agents - pharmacology Biological and medical sciences Cricetinae General and cellular metabolism. Vitamins Male Medical sciences Mesocricetus Microsomes, Liver - enzymology Pharmacology. Drug treatments Sterol O-Acyltransferase - antagonists & inhibitors Structure-Activity Relationship
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