Effect of Simmondsin Derivatives on Food Intake: Dose−Response Curves in Rats
Simmondsin is a food intake-reducing molecule found in the seeds of the jojoba plant (Simmondsia chinensis). Three naturally occurring analogues of simmondsin, simmondsin 2‘-trans-ferulate, 4-demethylsimmondsin, and 4,5-didemethylsimmondsin, were tested for anorexic properties, and dose response cur...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 1998-05, Vol.46 (5), p.1910-1913 |
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| container_end_page | 1913 |
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| container_issue | 5 |
| container_start_page | 1910 |
| container_title | Journal of agricultural and food chemistry |
| container_volume | 46 |
| creator | Flo, Gerda Van Boven, Maurits Vermaut, Sabien Decuypere, Eddy Daenens, Paul Cokelaere, Marnix |
| description | Simmondsin is a food intake-reducing molecule found in the seeds of the jojoba plant (Simmondsia chinensis). Three naturally occurring analogues of simmondsin, simmondsin 2‘-trans-ferulate, 4-demethylsimmondsin, and 4,5-didemethylsimmondsin, were tested for anorexic properties, and dose response curves were constructed. Demethylsimmondsin and didemethylsimmondsin showed no anorexic properties, while simmondsin 2‘-trans-ferulate showed dose-dependent food intake-reducing activity, but, on an equimolar basis, was less active than simmondsin. The food intake-reducing activity of two synthetic derivatives of simmondsin, hydroxymethoxyphenylacetonitrile and simmondsinamide, was also determined, and both were found to be inactive. Keywords: Simmondsin; simmondsin derivatives; jojoba meal; food intake; rats |
| doi_str_mv | 10.1021/jf971002e |
| format | Article |
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Three naturally occurring analogues of simmondsin, simmondsin 2‘-trans-ferulate, 4-demethylsimmondsin, and 4,5-didemethylsimmondsin, were tested for anorexic properties, and dose response curves were constructed. Demethylsimmondsin and didemethylsimmondsin showed no anorexic properties, while simmondsin 2‘-trans-ferulate showed dose-dependent food intake-reducing activity, but, on an equimolar basis, was less active than simmondsin. The food intake-reducing activity of two synthetic derivatives of simmondsin, hydroxymethoxyphenylacetonitrile and simmondsinamide, was also determined, and both were found to be inactive. Keywords: Simmondsin; simmondsin derivatives; jojoba meal; food intake; rats</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf971002e</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>ANALOGS ; ANOREXIC EFFECTS ; APETITO ; APPETIT ; APPETITE ; Biological and medical sciences ; DOSAGE EFFECTS ; DRUGS ; EFECTOS DE DOSIFICACION ; EFFET DOSE ; FOOD INTAKE ; General pharmacology ; GLICOSIDOS ; GLYCOSIDE ; GLYCOSIDES ; INGESTION DE ALIMENTOS ; Medical sciences ; MEDICAMENT ; MEDICAMENTOS ; MEDICINAL PROPERTIES ; OILSEED CAKES ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; PRISE ALIMENTAIRE (HOMME) ; PROPIEDADES MEDICINALES ; PROPRIETE PHARMACOLOGIQUE ; RAT ; RATA ; RATS ; SIMMONDSIA CHINENSIS ; TORTAS OLEAGINOSAS ; TOURTEAU D'OLEAGINEUX</subject><ispartof>Journal of agricultural and food chemistry, 1998-05, Vol.46 (5), p.1910-1913</ispartof><rights>Copyright © 1998 American Chemical Society</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a346t-b296a3d8b95430fd34431cdbc4678de5063dcbbbbb6b02c0157e5c4f069850b23</citedby><cites>FETCH-LOGICAL-a346t-b296a3d8b95430fd34431cdbc4678de5063dcbbbbb6b02c0157e5c4f069850b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf971002e$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf971002e$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2764,27075,27923,27924,56737,56787</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2257721$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Flo, Gerda</creatorcontrib><creatorcontrib>Van Boven, Maurits</creatorcontrib><creatorcontrib>Vermaut, Sabien</creatorcontrib><creatorcontrib>Decuypere, Eddy</creatorcontrib><creatorcontrib>Daenens, Paul</creatorcontrib><creatorcontrib>Cokelaere, Marnix</creatorcontrib><title>Effect of Simmondsin Derivatives on Food Intake: Dose−Response Curves in Rats</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Simmondsin is a food intake-reducing molecule found in the seeds of the jojoba plant (Simmondsia chinensis). Three naturally occurring analogues of simmondsin, simmondsin 2‘-trans-ferulate, 4-demethylsimmondsin, and 4,5-didemethylsimmondsin, were tested for anorexic properties, and dose response curves were constructed. Demethylsimmondsin and didemethylsimmondsin showed no anorexic properties, while simmondsin 2‘-trans-ferulate showed dose-dependent food intake-reducing activity, but, on an equimolar basis, was less active than simmondsin. The food intake-reducing activity of two synthetic derivatives of simmondsin, hydroxymethoxyphenylacetonitrile and simmondsinamide, was also determined, and both were found to be inactive. Keywords: Simmondsin; simmondsin derivatives; jojoba meal; food intake; rats</description><subject>ANALOGS</subject><subject>ANOREXIC EFFECTS</subject><subject>APETITO</subject><subject>APPETIT</subject><subject>APPETITE</subject><subject>Biological and medical sciences</subject><subject>DOSAGE EFFECTS</subject><subject>DRUGS</subject><subject>EFECTOS DE DOSIFICACION</subject><subject>EFFET DOSE</subject><subject>FOOD INTAKE</subject><subject>General pharmacology</subject><subject>GLICOSIDOS</subject><subject>GLYCOSIDE</subject><subject>GLYCOSIDES</subject><subject>INGESTION DE ALIMENTOS</subject><subject>Medical sciences</subject><subject>MEDICAMENT</subject><subject>MEDICAMENTOS</subject><subject>MEDICINAL PROPERTIES</subject><subject>OILSEED CAKES</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>PRISE ALIMENTAIRE (HOMME)</subject><subject>PROPIEDADES MEDICINALES</subject><subject>PROPRIETE PHARMACOLOGIQUE</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>SIMMONDSIA CHINENSIS</subject><subject>TORTAS OLEAGINOSAS</subject><subject>TOURTEAU D'OLEAGINEUX</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNptkEtLxDAUhYMoOD4W_gChC124qN4kTZO6k9HxgaLMQ8FNSNNEOo9mSDqiO5e69Sf6S-xQmZV3c-Ge7xwuB6E9DMcYCD4Z24xjAGLWUAczAjHDWKyjTnPCsWAp3kRbIYwBQDAOHdS_sNboOnI2GpSzmauKUFbRufHlq6rLVxMiV0U954rouqrVxJz-fHxF5y6Yn8_vvglzVwUTdRd-STbGvqrDDtqwahrM7t_eRqPexbB7Fd_eX153z25jRZO0jnOSpYoWIs9YQsEWNEko1kWuk5SLwjBIaaHz5aQ5EA2YccN0YiHNBIOc0G101OZq70Lwxsq5L2fKv0sMclmGXJXRsActO1dBq6n1qtJlWBkIYZwT3GBxi5WhNm8rWfmJTDnlTA4fBvImE4_PD09U3jX8fstb5aR68U3kaICzjEOGhUga_bDVlQ5y7Ba-agr5571fO_qDyw</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>Flo, Gerda</creator><creator>Van Boven, Maurits</creator><creator>Vermaut, Sabien</creator><creator>Decuypere, Eddy</creator><creator>Daenens, Paul</creator><creator>Cokelaere, Marnix</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19980501</creationdate><title>Effect of Simmondsin Derivatives on Food Intake: Dose−Response Curves in Rats</title><author>Flo, Gerda ; Van Boven, Maurits ; Vermaut, Sabien ; Decuypere, Eddy ; Daenens, Paul ; Cokelaere, Marnix</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a346t-b296a3d8b95430fd34431cdbc4678de5063dcbbbbb6b02c0157e5c4f069850b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>ANALOGS</topic><topic>ANOREXIC EFFECTS</topic><topic>APETITO</topic><topic>APPETIT</topic><topic>APPETITE</topic><topic>Biological and medical sciences</topic><topic>DOSAGE EFFECTS</topic><topic>DRUGS</topic><topic>EFECTOS DE DOSIFICACION</topic><topic>EFFET DOSE</topic><topic>FOOD INTAKE</topic><topic>General pharmacology</topic><topic>GLICOSIDOS</topic><topic>GLYCOSIDE</topic><topic>GLYCOSIDES</topic><topic>INGESTION DE ALIMENTOS</topic><topic>Medical sciences</topic><topic>MEDICAMENT</topic><topic>MEDICAMENTOS</topic><topic>MEDICINAL PROPERTIES</topic><topic>OILSEED CAKES</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>PRISE ALIMENTAIRE (HOMME)</topic><topic>PROPIEDADES MEDICINALES</topic><topic>PROPRIETE PHARMACOLOGIQUE</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>SIMMONDSIA CHINENSIS</topic><topic>TORTAS OLEAGINOSAS</topic><topic>TOURTEAU D'OLEAGINEUX</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flo, Gerda</creatorcontrib><creatorcontrib>Van Boven, Maurits</creatorcontrib><creatorcontrib>Vermaut, Sabien</creatorcontrib><creatorcontrib>Decuypere, Eddy</creatorcontrib><creatorcontrib>Daenens, Paul</creatorcontrib><creatorcontrib>Cokelaere, Marnix</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flo, Gerda</au><au>Van Boven, Maurits</au><au>Vermaut, Sabien</au><au>Decuypere, Eddy</au><au>Daenens, Paul</au><au>Cokelaere, Marnix</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Simmondsin Derivatives on Food Intake: Dose−Response Curves in Rats</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>46</volume><issue>5</issue><spage>1910</spage><epage>1913</epage><pages>1910-1913</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>Simmondsin is a food intake-reducing molecule found in the seeds of the jojoba plant (Simmondsia chinensis). Three naturally occurring analogues of simmondsin, simmondsin 2‘-trans-ferulate, 4-demethylsimmondsin, and 4,5-didemethylsimmondsin, were tested for anorexic properties, and dose response curves were constructed. Demethylsimmondsin and didemethylsimmondsin showed no anorexic properties, while simmondsin 2‘-trans-ferulate showed dose-dependent food intake-reducing activity, but, on an equimolar basis, was less active than simmondsin. The food intake-reducing activity of two synthetic derivatives of simmondsin, hydroxymethoxyphenylacetonitrile and simmondsinamide, was also determined, and both were found to be inactive. Keywords: Simmondsin; simmondsin derivatives; jojoba meal; food intake; rats</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><doi>10.1021/jf971002e</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8561 |
| ispartof | Journal of agricultural and food chemistry, 1998-05, Vol.46 (5), p.1910-1913 |
| issn | 0021-8561 1520-5118 |
| language | eng |
| recordid | cdi_crossref_primary_10_1021_jf971002e |
| source | ACS Publications |
| subjects | ANALOGS ANOREXIC EFFECTS APETITO APPETIT APPETITE Biological and medical sciences DOSAGE EFFECTS DRUGS EFECTOS DE DOSIFICACION EFFET DOSE FOOD INTAKE General pharmacology GLICOSIDOS GLYCOSIDE GLYCOSIDES INGESTION DE ALIMENTOS Medical sciences MEDICAMENT MEDICAMENTOS MEDICINAL PROPERTIES OILSEED CAKES Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments PRISE ALIMENTAIRE (HOMME) PROPIEDADES MEDICINALES PROPRIETE PHARMACOLOGIQUE RAT RATA RATS SIMMONDSIA CHINENSIS TORTAS OLEAGINOSAS TOURTEAU D'OLEAGINEUX |
| title | Effect of Simmondsin Derivatives on Food Intake: Dose−Response Curves in Rats |
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