Hypolipidemic Effect of Green Tea Leaves through Induction of Antioxidant and Phase II Enzymes Including Superoxide Dismutase, Catalase, and Glutathione S-Transferase in Rats
In this animal study, Wistar rats were fed 2.5% green tea (longjing) leaves, for 27 and 63 weeks; the changes of GOT, GPT, γ-GT, and creatinine were not significant in the treated group as compared with the control. These results suggested that long-term feeding of green tea leaves was not toxic to...
Gespeichert in:
| Veröffentlicht in: | Journal of agricultural and food chemistry 1998-05, Vol.46 (5), p.1893-1899 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1899 |
|---|---|
| container_issue | 5 |
| container_start_page | 1893 |
| container_title | Journal of agricultural and food chemistry |
| container_volume | 46 |
| creator | Lin, Yu-Li Cheng, Chong-Yurn Lin, Ya-Ping Lau, Yong-Wei Juan, I-Ming Lin, Jen-Kun |
| description | In this animal study, Wistar rats were fed 2.5% green tea (longjing) leaves, for 27 and 63 weeks; the changes of GOT, GPT, γ-GT, and creatinine were not significant in the treated group as compared with the control. These results suggested that long-term feeding of green tea leaves was not toxic to the liver or kidney. Serum total cholesterol, triglyceride, and LDL-C were decreased in the tested group. Interestingly, the dietary intakes of the two groups were approximately the same, but the body weights of the tea-fed group were decreased 10−18% compared with those of the control. The activities of antioxidant enzymes (SOD and catalase) and phase II enzyme (GST) and glutathione concentration in the liver of Wistar rats were significantly higher in the treated group. The biological significance of these results can be implicated in relation to the hypolipidemic effect as well as the cancer chemopreventive action of green tea. Keywords: Longjing tea; GST; HDL-C; hypolipidemic; LDL-C; phase II enzyme; SOD |
| doi_str_mv | 10.1021/jf970963q |
| format | Article |
| fullrecord | <record><control><sourceid>acs_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1021_jf970963q</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>d098298233</sourcerecordid><originalsourceid>FETCH-LOGICAL-a346t-737ff3fd2164fe3bbeaceb31dcb9a434f5b9c5decc4c0c16d86ab8b6baccd7d43</originalsourceid><addsrcrecordid>eNptkM2O0zAUhS0EEmVgwQMgeQELJAJ2fpxkOSqljVSJEe1s2Fg3_mldUidjO2jKQ_GMOAR1xcpXPt899-gg9JqSj5Sk9NNJ1yWpWfbwBC1okZKkoLR6ihYkiklVMPocvfD-RAipipIs0O_NZeg7MxipzkbgldZKBNxrvHZKWbxXgLcKfiqPw9H14-GIGytHEUxvJ-rWxunRSLABg5X47ghe4abBK_vrco5bjRXdKI094N04KDexCn82_jyGSH7ASwjQ_Z2m9XUXv8Mxmiu8S_YOrNfKTZbG4m8Q_Ev0TEPn1at_7w26_7LaLzfJ9uu6Wd5uE8hyFpIyK7XOtEwpy7XK2laBUG1GpWhryLNcF20tCqmEyAURlMmKQVu1rAUhZCnz7Aa9n32F6713SvPBmTO4C6eET0Xza9GRfTuzA3gBnY6phfHXhTQtypJWEUtmzPigHq8yuB-cxbwF39_teLFlNM82jH-P_JuZ19BzOLhoeb-j9XSVVhWN-rtZB-H5qR-djYX8J94faJulzw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Hypolipidemic Effect of Green Tea Leaves through Induction of Antioxidant and Phase II Enzymes Including Superoxide Dismutase, Catalase, and Glutathione S-Transferase in Rats</title><source>American Chemical Society Journals</source><creator>Lin, Yu-Li ; Cheng, Chong-Yurn ; Lin, Ya-Ping ; Lau, Yong-Wei ; Juan, I-Ming ; Lin, Jen-Kun</creator><creatorcontrib>Lin, Yu-Li ; Cheng, Chong-Yurn ; Lin, Ya-Ping ; Lau, Yong-Wei ; Juan, I-Ming ; Lin, Jen-Kun</creatorcontrib><description>In this animal study, Wistar rats were fed 2.5% green tea (longjing) leaves, for 27 and 63 weeks; the changes of GOT, GPT, γ-GT, and creatinine were not significant in the treated group as compared with the control. These results suggested that long-term feeding of green tea leaves was not toxic to the liver or kidney. Serum total cholesterol, triglyceride, and LDL-C were decreased in the tested group. Interestingly, the dietary intakes of the two groups were approximately the same, but the body weights of the tea-fed group were decreased 10−18% compared with those of the control. The activities of antioxidant enzymes (SOD and catalase) and phase II enzyme (GST) and glutathione concentration in the liver of Wistar rats were significantly higher in the treated group. The biological significance of these results can be implicated in relation to the hypolipidemic effect as well as the cancer chemopreventive action of green tea. Keywords: Longjing tea; GST; HDL-C; hypolipidemic; LDL-C; phase II enzyme; SOD</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf970963q</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>ACTIVIDAD ENZIMATICA ; ACTIVITE ENZYMATIQUE ; ANTIOXIDANTES ; ANTIOXIDANTS ; ANTIOXYDANT ; Biological and medical sciences ; BLOOD LIPIDS ; BLOOD SERUM ; BODY WEIGHT ; CAMELLIA SINENSIS ; CATALASA ; CATALASE ; CHOLESTEROL ; COLESTEROL ; CREATINA ; CREATINE ; DRUGS ; ENZYMIC ACTIVITY ; Feeding. Feeding behavior ; FEUILLE ; FOIE ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; GLUTATHIONE TRANSFERASE ; HEMOLIPIDOS ; HIGADO ; HIGH DENSITY LIPOPROTEIN ; HOJAS ; HYPOLIPEMIC AGENTS ; INTAKE ; KIDNEYS ; LEAVES ; LIPIDE SANGUIN ; LIPOPROTEINAS ; LIPOPROTEINE ; LIPOPROTEINS ; LIVER ; LONGJING TEA ; LOW DENSITY LIPOPROTEIN ; Medical sciences ; MEDICAMENT ; MEDICAMENTOS ; PESO CORPORAL ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; POIDS CORPOREL ; RAT ; RATA ; RATS ; REIN ; RINONES ; SERUM SANGUIN ; SUERO SANGUINEO ; SUPEROXIDE DISMUTASE ; SUPEROXIDO DISMUTASA ; SUPEROXYDE DISMUTASE ; TEA ; THE ; TRANSFERASAS ; TRANSFERASE ; TRANSFERASES ; TRIGLICERIDOS ; TRIGLYCERIDE ; TRIGLYCERIDES ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of agricultural and food chemistry, 1998-05, Vol.46 (5), p.1893-1899</ispartof><rights>Copyright © 1998 American Chemical Society</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a346t-737ff3fd2164fe3bbeaceb31dcb9a434f5b9c5decc4c0c16d86ab8b6baccd7d43</citedby><cites>FETCH-LOGICAL-a346t-737ff3fd2164fe3bbeaceb31dcb9a434f5b9c5decc4c0c16d86ab8b6baccd7d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf970963q$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf970963q$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2257718$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Yu-Li</creatorcontrib><creatorcontrib>Cheng, Chong-Yurn</creatorcontrib><creatorcontrib>Lin, Ya-Ping</creatorcontrib><creatorcontrib>Lau, Yong-Wei</creatorcontrib><creatorcontrib>Juan, I-Ming</creatorcontrib><creatorcontrib>Lin, Jen-Kun</creatorcontrib><title>Hypolipidemic Effect of Green Tea Leaves through Induction of Antioxidant and Phase II Enzymes Including Superoxide Dismutase, Catalase, and Glutathione S-Transferase in Rats</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>In this animal study, Wistar rats were fed 2.5% green tea (longjing) leaves, for 27 and 63 weeks; the changes of GOT, GPT, γ-GT, and creatinine were not significant in the treated group as compared with the control. These results suggested that long-term feeding of green tea leaves was not toxic to the liver or kidney. Serum total cholesterol, triglyceride, and LDL-C were decreased in the tested group. Interestingly, the dietary intakes of the two groups were approximately the same, but the body weights of the tea-fed group were decreased 10−18% compared with those of the control. The activities of antioxidant enzymes (SOD and catalase) and phase II enzyme (GST) and glutathione concentration in the liver of Wistar rats were significantly higher in the treated group. The biological significance of these results can be implicated in relation to the hypolipidemic effect as well as the cancer chemopreventive action of green tea. Keywords: Longjing tea; GST; HDL-C; hypolipidemic; LDL-C; phase II enzyme; SOD</description><subject>ACTIVIDAD ENZIMATICA</subject><subject>ACTIVITE ENZYMATIQUE</subject><subject>ANTIOXIDANTES</subject><subject>ANTIOXIDANTS</subject><subject>ANTIOXYDANT</subject><subject>Biological and medical sciences</subject><subject>BLOOD LIPIDS</subject><subject>BLOOD SERUM</subject><subject>BODY WEIGHT</subject><subject>CAMELLIA SINENSIS</subject><subject>CATALASA</subject><subject>CATALASE</subject><subject>CHOLESTEROL</subject><subject>COLESTEROL</subject><subject>CREATINA</subject><subject>CREATINE</subject><subject>DRUGS</subject><subject>ENZYMIC ACTIVITY</subject><subject>Feeding. Feeding behavior</subject><subject>FEUILLE</subject><subject>FOIE</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>GLUTATHIONE TRANSFERASE</subject><subject>HEMOLIPIDOS</subject><subject>HIGADO</subject><subject>HIGH DENSITY LIPOPROTEIN</subject><subject>HOJAS</subject><subject>HYPOLIPEMIC AGENTS</subject><subject>INTAKE</subject><subject>KIDNEYS</subject><subject>LEAVES</subject><subject>LIPIDE SANGUIN</subject><subject>LIPOPROTEINAS</subject><subject>LIPOPROTEINE</subject><subject>LIPOPROTEINS</subject><subject>LIVER</subject><subject>LONGJING TEA</subject><subject>LOW DENSITY LIPOPROTEIN</subject><subject>Medical sciences</subject><subject>MEDICAMENT</subject><subject>MEDICAMENTOS</subject><subject>PESO CORPORAL</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>POIDS CORPOREL</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>REIN</subject><subject>RINONES</subject><subject>SERUM SANGUIN</subject><subject>SUERO SANGUINEO</subject><subject>SUPEROXIDE DISMUTASE</subject><subject>SUPEROXIDO DISMUTASA</subject><subject>SUPEROXYDE DISMUTASE</subject><subject>TEA</subject><subject>THE</subject><subject>TRANSFERASAS</subject><subject>TRANSFERASE</subject><subject>TRANSFERASES</subject><subject>TRIGLICERIDOS</subject><subject>TRIGLYCERIDE</subject><subject>TRIGLYCERIDES</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNptkM2O0zAUhS0EEmVgwQMgeQELJAJ2fpxkOSqljVSJEe1s2Fg3_mldUidjO2jKQ_GMOAR1xcpXPt899-gg9JqSj5Sk9NNJ1yWpWfbwBC1okZKkoLR6ihYkiklVMPocvfD-RAipipIs0O_NZeg7MxipzkbgldZKBNxrvHZKWbxXgLcKfiqPw9H14-GIGytHEUxvJ-rWxunRSLABg5X47ghe4abBK_vrco5bjRXdKI094N04KDexCn82_jyGSH7ASwjQ_Z2m9XUXv8Mxmiu8S_YOrNfKTZbG4m8Q_Ev0TEPn1at_7w26_7LaLzfJ9uu6Wd5uE8hyFpIyK7XOtEwpy7XK2laBUG1GpWhryLNcF20tCqmEyAURlMmKQVu1rAUhZCnz7Aa9n32F6713SvPBmTO4C6eET0Xza9GRfTuzA3gBnY6phfHXhTQtypJWEUtmzPigHq8yuB-cxbwF39_teLFlNM82jH-P_JuZ19BzOLhoeb-j9XSVVhWN-rtZB-H5qR-djYX8J94faJulzw</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>Lin, Yu-Li</creator><creator>Cheng, Chong-Yurn</creator><creator>Lin, Ya-Ping</creator><creator>Lau, Yong-Wei</creator><creator>Juan, I-Ming</creator><creator>Lin, Jen-Kun</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19980501</creationdate><title>Hypolipidemic Effect of Green Tea Leaves through Induction of Antioxidant and Phase II Enzymes Including Superoxide Dismutase, Catalase, and Glutathione S-Transferase in Rats</title><author>Lin, Yu-Li ; Cheng, Chong-Yurn ; Lin, Ya-Ping ; Lau, Yong-Wei ; Juan, I-Ming ; Lin, Jen-Kun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a346t-737ff3fd2164fe3bbeaceb31dcb9a434f5b9c5decc4c0c16d86ab8b6baccd7d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>ACTIVIDAD ENZIMATICA</topic><topic>ACTIVITE ENZYMATIQUE</topic><topic>ANTIOXIDANTES</topic><topic>ANTIOXIDANTS</topic><topic>ANTIOXYDANT</topic><topic>Biological and medical sciences</topic><topic>BLOOD LIPIDS</topic><topic>BLOOD SERUM</topic><topic>BODY WEIGHT</topic><topic>CAMELLIA SINENSIS</topic><topic>CATALASA</topic><topic>CATALASE</topic><topic>CHOLESTEROL</topic><topic>COLESTEROL</topic><topic>CREATINA</topic><topic>CREATINE</topic><topic>DRUGS</topic><topic>ENZYMIC ACTIVITY</topic><topic>Feeding. Feeding behavior</topic><topic>FEUILLE</topic><topic>FOIE</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>GLUTATHIONE TRANSFERASE</topic><topic>HEMOLIPIDOS</topic><topic>HIGADO</topic><topic>HIGH DENSITY LIPOPROTEIN</topic><topic>HOJAS</topic><topic>HYPOLIPEMIC AGENTS</topic><topic>INTAKE</topic><topic>KIDNEYS</topic><topic>LEAVES</topic><topic>LIPIDE SANGUIN</topic><topic>LIPOPROTEINAS</topic><topic>LIPOPROTEINE</topic><topic>LIPOPROTEINS</topic><topic>LIVER</topic><topic>LONGJING TEA</topic><topic>LOW DENSITY LIPOPROTEIN</topic><topic>Medical sciences</topic><topic>MEDICAMENT</topic><topic>MEDICAMENTOS</topic><topic>PESO CORPORAL</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>POIDS CORPOREL</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>REIN</topic><topic>RINONES</topic><topic>SERUM SANGUIN</topic><topic>SUERO SANGUINEO</topic><topic>SUPEROXIDE DISMUTASE</topic><topic>SUPEROXIDO DISMUTASA</topic><topic>SUPEROXYDE DISMUTASE</topic><topic>TEA</topic><topic>THE</topic><topic>TRANSFERASAS</topic><topic>TRANSFERASE</topic><topic>TRANSFERASES</topic><topic>TRIGLICERIDOS</topic><topic>TRIGLYCERIDE</topic><topic>TRIGLYCERIDES</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Yu-Li</creatorcontrib><creatorcontrib>Cheng, Chong-Yurn</creatorcontrib><creatorcontrib>Lin, Ya-Ping</creatorcontrib><creatorcontrib>Lau, Yong-Wei</creatorcontrib><creatorcontrib>Juan, I-Ming</creatorcontrib><creatorcontrib>Lin, Jen-Kun</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Yu-Li</au><au>Cheng, Chong-Yurn</au><au>Lin, Ya-Ping</au><au>Lau, Yong-Wei</au><au>Juan, I-Ming</au><au>Lin, Jen-Kun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypolipidemic Effect of Green Tea Leaves through Induction of Antioxidant and Phase II Enzymes Including Superoxide Dismutase, Catalase, and Glutathione S-Transferase in Rats</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>46</volume><issue>5</issue><spage>1893</spage><epage>1899</epage><pages>1893-1899</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>In this animal study, Wistar rats were fed 2.5% green tea (longjing) leaves, for 27 and 63 weeks; the changes of GOT, GPT, γ-GT, and creatinine were not significant in the treated group as compared with the control. These results suggested that long-term feeding of green tea leaves was not toxic to the liver or kidney. Serum total cholesterol, triglyceride, and LDL-C were decreased in the tested group. Interestingly, the dietary intakes of the two groups were approximately the same, but the body weights of the tea-fed group were decreased 10−18% compared with those of the control. The activities of antioxidant enzymes (SOD and catalase) and phase II enzyme (GST) and glutathione concentration in the liver of Wistar rats were significantly higher in the treated group. The biological significance of these results can be implicated in relation to the hypolipidemic effect as well as the cancer chemopreventive action of green tea. Keywords: Longjing tea; GST; HDL-C; hypolipidemic; LDL-C; phase II enzyme; SOD</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><doi>10.1021/jf970963q</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8561 |
| ispartof | Journal of agricultural and food chemistry, 1998-05, Vol.46 (5), p.1893-1899 |
| issn | 0021-8561 1520-5118 |
| language | eng |
| recordid | cdi_crossref_primary_10_1021_jf970963q |
| source | American Chemical Society Journals |
| subjects | ACTIVIDAD ENZIMATICA ACTIVITE ENZYMATIQUE ANTIOXIDANTES ANTIOXIDANTS ANTIOXYDANT Biological and medical sciences BLOOD LIPIDS BLOOD SERUM BODY WEIGHT CAMELLIA SINENSIS CATALASA CATALASE CHOLESTEROL COLESTEROL CREATINA CREATINE DRUGS ENZYMIC ACTIVITY Feeding. Feeding behavior FEUILLE FOIE Fundamental and applied biological sciences. Psychology General pharmacology GLUTATHIONE TRANSFERASE HEMOLIPIDOS HIGADO HIGH DENSITY LIPOPROTEIN HOJAS HYPOLIPEMIC AGENTS INTAKE KIDNEYS LEAVES LIPIDE SANGUIN LIPOPROTEINAS LIPOPROTEINE LIPOPROTEINS LIVER LONGJING TEA LOW DENSITY LIPOPROTEIN Medical sciences MEDICAMENT MEDICAMENTOS PESO CORPORAL Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments POIDS CORPOREL RAT RATA RATS REIN RINONES SERUM SANGUIN SUERO SANGUINEO SUPEROXIDE DISMUTASE SUPEROXIDO DISMUTASA SUPEROXYDE DISMUTASE TEA THE TRANSFERASAS TRANSFERASE TRANSFERASES TRIGLICERIDOS TRIGLYCERIDE TRIGLYCERIDES Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Hypolipidemic Effect of Green Tea Leaves through Induction of Antioxidant and Phase II Enzymes Including Superoxide Dismutase, Catalase, and Glutathione S-Transferase in Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T06%3A14%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-acs_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hypolipidemic%20Effect%20of%20Green%20Tea%20Leaves%20through%20Induction%20of%20Antioxidant%20and%20Phase%20II%20Enzymes%20Including%20Superoxide%20Dismutase,%20Catalase,%20and%20Glutathione%20S-Transferase%20in%20Rats&rft.jtitle=Journal%20of%20agricultural%20and%20food%20chemistry&rft.au=Lin,%20Yu-Li&rft.date=1998-05-01&rft.volume=46&rft.issue=5&rft.spage=1893&rft.epage=1899&rft.pages=1893-1899&rft.issn=0021-8561&rft.eissn=1520-5118&rft.coden=JAFCAU&rft_id=info:doi/10.1021/jf970963q&rft_dat=%3Cacs_cross%3Ed098298233%3C/acs_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |