Synthesis and Fungicidal Evaluation of 2-Arylphenyl Ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol Derivatives
A series of novel 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives were designed and synthesized as candidate fungicides. The new compounds were identified by 1H NMR spectroscopy and element analysis. Their antifungal activities were evaluated. They exhibited excellent antifungal...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2009-06, Vol.57 (11), p.4854-4860 |
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| container_end_page | 4860 |
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| container_issue | 11 |
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| container_title | Journal of agricultural and food chemistry |
| container_volume | 57 |
| creator | Yu, Guan-Ping Xu, Liang-Zhong Yi, Xu Bi, Wen-Zhao Zhu, Qi Zhai, Zhi-Wei |
| description | A series of novel 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives were designed and synthesized as candidate fungicides. The new compounds were identified by 1H NMR spectroscopy and element analysis. Their antifungal activities were evaluated. They exhibited excellent antifungal activities against five common pathogens in comparison with the commercial fungicides tebuconazole and difenoconazole. The antifungal activities of three new triazole alcohol compounds were compared with those of tebuconazole and difenoconazole at a concentration of 1 μg/mL. |
| doi_str_mv | 10.1021/jf900222s |
| format | Article |
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The new compounds were identified by 1H NMR spectroscopy and element analysis. Their antifungal activities were evaluated. They exhibited excellent antifungal activities against five common pathogens in comparison with the commercial fungicides tebuconazole and difenoconazole. The antifungal activities of three new triazole alcohol compounds were compared with those of tebuconazole and difenoconazole at a concentration of 1 μg/mL.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf900222s</identifier><identifier>PMID: 19422214</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>antifungal properties ; Biological and medical sciences ; Crop and Animal Protection Chemistry ; difenoconazole ; elements ; Food industries ; Fundamental and applied biological sciences. Psychology ; fungi ; Fungi - drug effects ; Fungicides, Industrial - chemical synthesis ; Fungicides, Industrial - chemistry ; Fungicides, Industrial - pharmacology ; new products ; nuclear magnetic resonance spectroscopy ; Plant Diseases - microbiology ; plant pathogenic fungi ; product development ; Propanols - chemical synthesis ; Propanols - chemistry ; Propanols - pharmacology ; tebuconazole ; triazole fungicides ; Triazoles - chemical synthesis ; Triazoles - chemistry ; Triazoles - pharmacology</subject><ispartof>Journal of agricultural and food chemistry, 2009-06, Vol.57 (11), p.4854-4860</ispartof><rights>Copyright © 2009 American Chemical Society</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a367t-e505a3b9ba2e86c03b901fd290e019522952952724423d4a66334995eb1722ff3</citedby><cites>FETCH-LOGICAL-a367t-e505a3b9ba2e86c03b901fd290e019522952952724423d4a66334995eb1722ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf900222s$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf900222s$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21567703$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19422214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Guan-Ping</creatorcontrib><creatorcontrib>Xu, Liang-Zhong</creatorcontrib><creatorcontrib>Yi, Xu</creatorcontrib><creatorcontrib>Bi, Wen-Zhao</creatorcontrib><creatorcontrib>Zhu, Qi</creatorcontrib><creatorcontrib>Zhai, Zhi-Wei</creatorcontrib><title>Synthesis and Fungicidal Evaluation of 2-Arylphenyl Ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol Derivatives</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>A series of novel 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives were designed and synthesized as candidate fungicides. The new compounds were identified by 1H NMR spectroscopy and element analysis. Their antifungal activities were evaluated. They exhibited excellent antifungal activities against five common pathogens in comparison with the commercial fungicides tebuconazole and difenoconazole. The antifungal activities of three new triazole alcohol compounds were compared with those of tebuconazole and difenoconazole at a concentration of 1 μg/mL.</description><subject>antifungal properties</subject><subject>Biological and medical sciences</subject><subject>Crop and Animal Protection Chemistry</subject><subject>difenoconazole</subject><subject>elements</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>fungi</subject><subject>Fungi - drug effects</subject><subject>Fungicides, Industrial - chemical synthesis</subject><subject>Fungicides, Industrial - chemistry</subject><subject>Fungicides, Industrial - pharmacology</subject><subject>new products</subject><subject>nuclear magnetic resonance spectroscopy</subject><subject>Plant Diseases - microbiology</subject><subject>plant pathogenic fungi</subject><subject>product development</subject><subject>Propanols - chemical synthesis</subject><subject>Propanols - chemistry</subject><subject>Propanols - pharmacology</subject><subject>tebuconazole</subject><subject>triazole fungicides</subject><subject>Triazoles - chemical synthesis</subject><subject>Triazoles - chemistry</subject><subject>Triazoles - pharmacology</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0F1LwzAUBuAgipsfF_4B7Y2gYPSck6ZdL8ecHyB4oV6XszbRjq4tyTaov97IhnohJCQkT17CK8QJwjUC4c3cZgBE5HfEEDWB1IijXTEMhyhHOsGBOPB-DgAjncK-GGAWB47xUMxf-mb5YXzlI27K6G7VvFdFVXIdTddcr3hZtU3U2ojk2PV192GaPlyFF04qeYEPEq_oKpZLV_FnW0uUfX3ZubbjRpJs6-jWuGodUtbGH4k9y7U3x9v1ULzdTV8nD_Lp-f5xMn6SrJJ0KY0GzWqWzZjMKCkgbAFtSRkYwEwThRlGSnFMqow5SZSKs0ybGaZE1qpDcbnJLVzrvTM271y1YNfnCPl3X_lPX8Gebmy3mi1M-Su3BQVwvgXsC66t46ao_I8j1EmaggrubOMstzm_u2DeXghQASZxov4mceHzebtyTSjhny99AVj3hGg</recordid><startdate>20090610</startdate><enddate>20090610</enddate><creator>Yu, Guan-Ping</creator><creator>Xu, Liang-Zhong</creator><creator>Yi, Xu</creator><creator>Bi, Wen-Zhao</creator><creator>Zhu, Qi</creator><creator>Zhai, Zhi-Wei</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20090610</creationdate><title>Synthesis and Fungicidal Evaluation of 2-Arylphenyl Ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol Derivatives</title><author>Yu, Guan-Ping ; Xu, Liang-Zhong ; Yi, Xu ; Bi, Wen-Zhao ; Zhu, Qi ; Zhai, Zhi-Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a367t-e505a3b9ba2e86c03b901fd290e019522952952724423d4a66334995eb1722ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>antifungal properties</topic><topic>Biological and medical sciences</topic><topic>Crop and Animal Protection Chemistry</topic><topic>difenoconazole</topic><topic>elements</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>fungi</topic><topic>Fungi - drug effects</topic><topic>Fungicides, Industrial - chemical synthesis</topic><topic>Fungicides, Industrial - chemistry</topic><topic>Fungicides, Industrial - pharmacology</topic><topic>new products</topic><topic>nuclear magnetic resonance spectroscopy</topic><topic>Plant Diseases - microbiology</topic><topic>plant pathogenic fungi</topic><topic>product development</topic><topic>Propanols - chemical synthesis</topic><topic>Propanols - chemistry</topic><topic>Propanols - pharmacology</topic><topic>tebuconazole</topic><topic>triazole fungicides</topic><topic>Triazoles - chemical synthesis</topic><topic>Triazoles - chemistry</topic><topic>Triazoles - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Guan-Ping</creatorcontrib><creatorcontrib>Xu, Liang-Zhong</creatorcontrib><creatorcontrib>Yi, Xu</creatorcontrib><creatorcontrib>Bi, Wen-Zhao</creatorcontrib><creatorcontrib>Zhu, Qi</creatorcontrib><creatorcontrib>Zhai, Zhi-Wei</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Guan-Ping</au><au>Xu, Liang-Zhong</au><au>Yi, Xu</au><au>Bi, Wen-Zhao</au><au>Zhu, Qi</au><au>Zhai, Zhi-Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and Fungicidal Evaluation of 2-Arylphenyl Ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol Derivatives</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2009-06-10</date><risdate>2009</risdate><volume>57</volume><issue>11</issue><spage>4854</spage><epage>4860</epage><pages>4854-4860</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>A series of novel 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives were designed and synthesized as candidate fungicides. The new compounds were identified by 1H NMR spectroscopy and element analysis. Their antifungal activities were evaluated. They exhibited excellent antifungal activities against five common pathogens in comparison with the commercial fungicides tebuconazole and difenoconazole. The antifungal activities of three new triazole alcohol compounds were compared with those of tebuconazole and difenoconazole at a concentration of 1 μg/mL.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>19422214</pmid><doi>10.1021/jf900222s</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of agricultural and food chemistry, 2009-06, Vol.57 (11), p.4854-4860 |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | antifungal properties Biological and medical sciences Crop and Animal Protection Chemistry difenoconazole elements Food industries Fundamental and applied biological sciences. Psychology fungi Fungi - drug effects Fungicides, Industrial - chemical synthesis Fungicides, Industrial - chemistry Fungicides, Industrial - pharmacology new products nuclear magnetic resonance spectroscopy Plant Diseases - microbiology plant pathogenic fungi product development Propanols - chemical synthesis Propanols - chemistry Propanols - pharmacology tebuconazole triazole fungicides Triazoles - chemical synthesis Triazoles - chemistry Triazoles - pharmacology |
| title | Synthesis and Fungicidal Evaluation of 2-Arylphenyl Ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol Derivatives |
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