Curcumin Exerts Antidifferentiation Effect through AMPKα-PPAR-γ in 3T3-L1 Adipocytes and Antiproliferatory Effect through AMPKα-COX-2 in Cancer Cells

Curcumin has been reported to have the potential to prevent obesity as well as cancers. The downstream targets regulated by AMP-activated protein kinase (AMPK) for inhibiting adipocyte differentiation or cancer cell proliferation of curcumin were investigated. The activation of AMPK by curcumin was...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2009-01, Vol.57 (1), p.305-310
Hauptverfasser:	Lee, Yun K, Lee, Won S, Hwang, Jin T, Kwon, Dae Y, Surh, Young J, Park, Ock J
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 adipocytes adipocytes AMP-activated protein kinase anticarcinogenic activity breast neoplasms cell lines cell proliferation curcumin fibroblasts MCF-7 cells Molecular Nutrition neoplasms peroxisome proliferator-activated receptor-gamma prostaglandin synthase protein kinases transcription factors
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