Soyasaponins Ab and Bb Prevent Scopolamine-Induced Memory Impairment in Mice without the Inhibition of Acetylcholinesterase

Soy (Glycine max, family Leguminosae), which contains isoflavones and saponins as main constituents, is known to exhibit memory-enhancing effects. Therefore, to investigate the role of soyasaponins in memory impairments, we isolated soyasaponins Ab (SA) and Bb (SB) from soybean and measured their pr...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2014-03, Vol.62 (9), p.2062-2068
Hauptverfasser:	Hong, Sung-Woon, Yoo, Dae-Hyung, Woo, Jae-Yeon, Jeong, Jin-Ju, Yang, Jeong-hwa, Kim, Dong-Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholinesterase Acetylcholinesterase - metabolism Animals Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Cholinesterase Inhibitors - administration & dosage cyclic AMP Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Glycine max Glycine max - chemistry hippocampus Humans isoflavones Male memory Memory Disorders - chemically induced Memory Disorders - drug therapy Memory Disorders - enzymology Memory Disorders - genetics Mice Mice, Inbred ICR Phytotherapy Plant Extracts - administration & dosage protective effect protein phosphorylation saponins Saponins - administration & dosage Scopolamine - adverse effects soybeans
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