Topoisomerase II-Targeting Properties of a Grapevine-Shoot Extract and Resveratrol Oligomers

Grapevine-shoot extracts (GSE), containing trans-resveratrol and resveratrol oligomers, are commercially available as food supplements. Considering the topoisomerase-targeting properties of trans-resveratrol, the question of whether GSE affect these enzymes, thereby potentially causing DNA damage, w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of agricultural and food chemistry 2014-01, Vol.62 (3), p.780-788
Hauptverfasser:	Baechler, Simone A, Schroeter, Anika, Dicker, Martina, Steinberg, Pablo, Marko, Doris
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - metabolism bioassays Biocatalysis - drug effects catalytic activity Cell Line, Tumor Comet Assay dietary supplements DNA DNA damage DNA Damage - drug effects DNA topoisomerase (ATP-hydrolysing) DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Plant Extracts - chemistry Plant Extracts - pharmacology Plant Shoots - chemistry resveratrol Stilbenes - chemistry Stilbenes - pharmacology viniferins Vitis - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!