The Gut Microbiota Ellagic Acid-Derived Metabolite Urolithin A and Its Sulfate Conjugate Are Substrates for the Drug Efflux Transporter Breast Cancer Resistance Protein (ABCG2/BCRP)

The breast cancer resistance protein (BCRP/ABCG2) is a drug efflux transporter that can affect the pharmacological and toxicological properties of many molecules. Urolithins, metabolites produced by the gut microbiota from ellagic acid (EA) and ellagitannins, have been acknowledged with in vivo anti...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2013-05, Vol.61 (18), p.4352-4359
Hauptverfasser:	González-Sarrías, Antonio, Miguel, Verónica, Merino, Gracia, Lucas, Ricardo, Morales, Juan C, Tomás-Barberán, Francisco, Álvarez, Ana I, Espín, Juan C
Format:	Artikel
Sprache:	eng
Schlagworte:	active transport Adenosine - analogs & derivatives Adenosine - pharmacology Animals Anti-Inflammatory Agents - pharmacology antineoplastic agents Antineoplastic Agents - pharmacology ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biological and medical sciences breast neoplasms Breast Neoplasms - drug therapy Breast Neoplasms - genetics Cattle Cell Line, Tumor chemoprevention Coumarins - pharmacology digestive system Diketopiperazines Dogs drug resistance ellagic acid Ellagic Acid - metabolism Female flow cytometry Food industries Fundamental and applied biological sciences. Psychology Glucuronides - pharmacology Heterocyclic Compounds, 4 or More Rings Humans Hydrolyzable Tannins - metabolism intestinal microorganisms Madin Darby Canine Kidney Cells metabolites Mice Microbiota Mitoxantrone - pharmacology Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Sheep Sulfates - metabolism
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