Residue Depletion of Tilmicosin in Cattle after Subcutaneous Administration
A study of tissue residue depletion of tilmicosin in cattle was conducted after a single subcutaneous injection at the therapeutic level of 10 mg per kg body weight. Eighteen cross cattle were treated with the tilmicosin oil formulation (30%). Three treated animals (two males and one female) were se...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2006-07, Vol.54 (14), p.5208-5213 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Jiang, Haiyang Ding, Shuangyang Li, Jiancheng An, Dianjin Li, Cun Shen, Jianzhong |
| description | A study of tissue residue depletion of tilmicosin in cattle was conducted after a single subcutaneous injection at the therapeutic level of 10 mg per kg body weight. Eighteen cross cattle were treated with the tilmicosin oil formulation (30%). Three treated animals (two males and one female) were selected randomly to be scarified at 1, 7, 14, 28, and 35 days withdrawal after injection. Samples of the injection site and of muscle, liver, kidney, and fat were collected. Tilmicosin residue concentrations were determined using a high-performance liquid chromatography (HPLC) method with a UV detector at 290 nm. Using a statistical method recommended by the Committee for Veterinary Medical Products of European Medical Evaluation Agency, the withdrawal time of 34 days was established when all tissue residues except samples in the injection site were below the accepted maximum residue limits. Keywords: Tilmicosin; residue; depletion; cattle; withdrawal time |
| doi_str_mv | 10.1021/jf060863x |
| format | Article |
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Eighteen cross cattle were treated with the tilmicosin oil formulation (30%). Three treated animals (two males and one female) were selected randomly to be scarified at 1, 7, 14, 28, and 35 days withdrawal after injection. Samples of the injection site and of muscle, liver, kidney, and fat were collected. Tilmicosin residue concentrations were determined using a high-performance liquid chromatography (HPLC) method with a UV detector at 290 nm. Using a statistical method recommended by the Committee for Veterinary Medical Products of European Medical Evaluation Agency, the withdrawal time of 34 days was established when all tissue residues except samples in the injection site were below the accepted maximum residue limits. Keywords: Tilmicosin; residue; depletion; cattle; withdrawal time</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf060863x</identifier><identifier>PMID: 16819937</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Adipose Tissue - chemistry ; Animals ; Anti-Bacterial Agents ; Biological and medical sciences ; cattle ; Cattle - metabolism ; Chromatography, High Pressure Liquid ; drug residues ; Drug Residues - analysis ; Female ; Food industries ; Fundamental and applied biological sciences. Psychology ; injection site ; Injections, Subcutaneous ; Kidney - chemistry ; Liver - chemistry ; macrolide antibiotics ; Macrolides - administration & dosage ; Macrolides - pharmacokinetics ; Male ; Muscle, Skeletal - chemistry ; pharmacokinetics ; Sensitivity and Specificity ; subcutaneous injection ; tilmicosin ; Tylosin - administration & dosage ; Tylosin - analogs & derivatives ; Tylosin - pharmacokinetics</subject><ispartof>Journal of agricultural and food chemistry, 2006-07, Vol.54 (14), p.5208-5213</ispartof><rights>Copyright © 2006 American Chemical Society</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a405t-7928a5f17e038e61e5443e7a2ad89d2ef8b86d4c675fadb554635fd097f74f383</citedby><cites>FETCH-LOGICAL-a405t-7928a5f17e038e61e5443e7a2ad89d2ef8b86d4c675fadb554635fd097f74f383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf060863x$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf060863x$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17940532$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16819937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Haiyang</creatorcontrib><creatorcontrib>Ding, Shuangyang</creatorcontrib><creatorcontrib>Li, Jiancheng</creatorcontrib><creatorcontrib>An, Dianjin</creatorcontrib><creatorcontrib>Li, Cun</creatorcontrib><creatorcontrib>Shen, Jianzhong</creatorcontrib><title>Residue Depletion of Tilmicosin in Cattle after Subcutaneous Administration</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>A study of tissue residue depletion of tilmicosin in cattle was conducted after a single subcutaneous injection at the therapeutic level of 10 mg per kg body weight. Eighteen cross cattle were treated with the tilmicosin oil formulation (30%). Three treated animals (two males and one female) were selected randomly to be scarified at 1, 7, 14, 28, and 35 days withdrawal after injection. Samples of the injection site and of muscle, liver, kidney, and fat were collected. Tilmicosin residue concentrations were determined using a high-performance liquid chromatography (HPLC) method with a UV detector at 290 nm. Using a statistical method recommended by the Committee for Veterinary Medical Products of European Medical Evaluation Agency, the withdrawal time of 34 days was established when all tissue residues except samples in the injection site were below the accepted maximum residue limits. Keywords: Tilmicosin; residue; depletion; cattle; withdrawal time</description><subject>Adipose Tissue - chemistry</subject><subject>Animals</subject><subject>Anti-Bacterial Agents</subject><subject>Biological and medical sciences</subject><subject>cattle</subject><subject>Cattle - metabolism</subject><subject>Chromatography, High Pressure Liquid</subject><subject>drug residues</subject><subject>Drug Residues - analysis</subject><subject>Female</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>injection site</subject><subject>Injections, Subcutaneous</subject><subject>Kidney - chemistry</subject><subject>Liver - chemistry</subject><subject>macrolide antibiotics</subject><subject>Macrolides - administration & dosage</subject><subject>Macrolides - pharmacokinetics</subject><subject>Male</subject><subject>Muscle, Skeletal - chemistry</subject><subject>pharmacokinetics</subject><subject>Sensitivity and Specificity</subject><subject>subcutaneous injection</subject><subject>tilmicosin</subject><subject>Tylosin - administration & dosage</subject><subject>Tylosin - analogs & derivatives</subject><subject>Tylosin - pharmacokinetics</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0EtLAzEQB_AgitbHwS-ge_HgYXWy2Tz2KK0vFHy0IngJ091EUre7JdmF-u2NtNiLEMhhfpnM_Ak5pnBBIaOXMwsClGDLLTKgPIOUU6q2yQBiMVVc0D2yH8IMABSXsEv2qFC0KJgckIdXE1zVm2RkFrXpXNskrU0mrp67sg2uSeIZYtfVJkHbGZ-M-2nZd9iYtg_JVTV3jQudx9-Xh2THYh3M0fo-IG8315PhXfr4dHs_vHpMMQfepbLIFHJLpQGmjKCG5zkzEjOsVFFlxqqpElVeCsktVlPOc8G4raCQVuaWKXZAzld9S9-G4I3VC-_m6L81Bf0biP4LJNqTlV3007mpNnKdQARna4ChxNp6bEoXNk4WcWiWRZeuXFzXLP_q6L-0kExyPXke64-hfH8ZfdzpUfSnK2-x1fjpY8-3cQaUAaUAObDNz1gGPWt738TQ_lnhBympjMM</recordid><startdate>20060712</startdate><enddate>20060712</enddate><creator>Jiang, Haiyang</creator><creator>Ding, Shuangyang</creator><creator>Li, Jiancheng</creator><creator>An, Dianjin</creator><creator>Li, Cun</creator><creator>Shen, Jianzhong</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20060712</creationdate><title>Residue Depletion of Tilmicosin in Cattle after Subcutaneous Administration</title><author>Jiang, Haiyang ; Ding, Shuangyang ; Li, Jiancheng ; An, Dianjin ; Li, Cun ; Shen, Jianzhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a405t-7928a5f17e038e61e5443e7a2ad89d2ef8b86d4c675fadb554635fd097f74f383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adipose Tissue - chemistry</topic><topic>Animals</topic><topic>Anti-Bacterial Agents</topic><topic>Biological and medical sciences</topic><topic>cattle</topic><topic>Cattle - metabolism</topic><topic>Chromatography, High Pressure Liquid</topic><topic>drug residues</topic><topic>Drug Residues - analysis</topic><topic>Female</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>injection site</topic><topic>Injections, Subcutaneous</topic><topic>Kidney - chemistry</topic><topic>Liver - chemistry</topic><topic>macrolide antibiotics</topic><topic>Macrolides - administration & dosage</topic><topic>Macrolides - pharmacokinetics</topic><topic>Male</topic><topic>Muscle, Skeletal - chemistry</topic><topic>pharmacokinetics</topic><topic>Sensitivity and Specificity</topic><topic>subcutaneous injection</topic><topic>tilmicosin</topic><topic>Tylosin - administration & dosage</topic><topic>Tylosin - analogs & derivatives</topic><topic>Tylosin - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Haiyang</creatorcontrib><creatorcontrib>Ding, Shuangyang</creatorcontrib><creatorcontrib>Li, Jiancheng</creatorcontrib><creatorcontrib>An, Dianjin</creatorcontrib><creatorcontrib>Li, Cun</creatorcontrib><creatorcontrib>Shen, Jianzhong</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Haiyang</au><au>Ding, Shuangyang</au><au>Li, Jiancheng</au><au>An, Dianjin</au><au>Li, Cun</au><au>Shen, Jianzhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Residue Depletion of Tilmicosin in Cattle after Subcutaneous Administration</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2006-07-12</date><risdate>2006</risdate><volume>54</volume><issue>14</issue><spage>5208</spage><epage>5213</epage><pages>5208-5213</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>A study of tissue residue depletion of tilmicosin in cattle was conducted after a single subcutaneous injection at the therapeutic level of 10 mg per kg body weight. Eighteen cross cattle were treated with the tilmicosin oil formulation (30%). Three treated animals (two males and one female) were selected randomly to be scarified at 1, 7, 14, 28, and 35 days withdrawal after injection. Samples of the injection site and of muscle, liver, kidney, and fat were collected. Tilmicosin residue concentrations were determined using a high-performance liquid chromatography (HPLC) method with a UV detector at 290 nm. Using a statistical method recommended by the Committee for Veterinary Medical Products of European Medical Evaluation Agency, the withdrawal time of 34 days was established when all tissue residues except samples in the injection site were below the accepted maximum residue limits. Keywords: Tilmicosin; residue; depletion; cattle; withdrawal time</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>16819937</pmid><doi>10.1021/jf060863x</doi><tpages>6</tpages></addata></record> |
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| subjects | Adipose Tissue - chemistry Animals Anti-Bacterial Agents Biological and medical sciences cattle Cattle - metabolism Chromatography, High Pressure Liquid drug residues Drug Residues - analysis Female Food industries Fundamental and applied biological sciences. Psychology injection site Injections, Subcutaneous Kidney - chemistry Liver - chemistry macrolide antibiotics Macrolides - administration & dosage Macrolides - pharmacokinetics Male Muscle, Skeletal - chemistry pharmacokinetics Sensitivity and Specificity subcutaneous injection tilmicosin Tylosin - administration & dosage Tylosin - analogs & derivatives Tylosin - pharmacokinetics |
| title | Residue Depletion of Tilmicosin in Cattle after Subcutaneous Administration |
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