Induction of Phase II Detoxification Enzymes in Rats by Plant-Derived Isothiocyanates: Comparison of Allyl Isothiocyanate with Sulforaphane and Related Compounds

Plants of the family Brassicaceae contain high levels of glucosinolates. The latter compounds are degraded to isothiocyanates, some of which have been shown to be potent inducers of phase II detoxification enzymes in vitro. In the present study, the ability of six plant-derived isothiocyanates (ally...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2004-04, Vol.52 (7), p.1867-1871
Hauptverfasser:	Munday, Rex, Munday, Christine M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brassicaceae - chemistry Enzyme Induction - drug effects Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Glutathione Transferase - biosynthesis Isothiocyanates - pharmacology NAD(P)H Dehydrogenase (Quinone) - biosynthesis Rats Rats, Sprague-Dawley Sulfides - pharmacology Sulfones - pharmacology Thiocyanates - pharmacology Urinary Bladder - enzymology Vertebrates: anatomy and physiology, studies on body, several organs or systems
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