Residue Depletion Study and Withdrawal Period for Flunixin-N-methyl Glucamine in Bovine Milk Following Intravenous Administration
The objective of this study was to establish a withdrawal period for flunixin in milk by quantifying 5-hydroxyflunixin, the marker residue, in bovine milk as a function of time, following intravenous treatment of lactating dairy cows with flunixin-N-methyl glucamine (Banamine or Finadyne). Lactating...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2003-07, Vol.51 (16), p.4701-4707 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Ngoh, Maureen A Wislocki, Peter G Thompson, Kenneth Katz, Terry Weingarten, Allan TerHune, Terry Hurshman, Bret |
| description | The objective of this study was to establish a withdrawal period for flunixin in milk by quantifying 5-hydroxyflunixin, the marker residue, in bovine milk as a function of time, following intravenous treatment of lactating dairy cows with flunixin-N-methyl glucamine (Banamine or Finadyne). Lactating dairy cows were dosed on three consecutive days at 2.2 mg of flunixin free acid/kg of body weight/day. Milk was collected twice daily and assayed using a liquid chromatography−mass spectrometry/mass spectrometry (LC-MS/MS) procedure. The method was validated at concentrations in the range 0.5−250 ppb. The concentrations for 5-hydroxyflunixin measured 12 h after the last administration of drug ranged from 1.56 to 40.6 ppb for all cows. Milk concentrations for 5-hydroxyflunixin were used to establish withdrawal periods of 36 h using guidelines established by the U.S. Food and Drug Administration/Center for Veterinary Medicine and 24 h using guidelines established by the European Medicinal Evaluation Agency/Committee on Veterinary Medicinal Products. Keywords: Flunixin meglumine; 5-Hydroxyflunixin; bovine milk; withdrawal period |
| doi_str_mv | 10.1021/jf026219+ |
| format | Article |
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Lactating dairy cows were dosed on three consecutive days at 2.2 mg of flunixin free acid/kg of body weight/day. Milk was collected twice daily and assayed using a liquid chromatography−mass spectrometry/mass spectrometry (LC-MS/MS) procedure. The method was validated at concentrations in the range 0.5−250 ppb. The concentrations for 5-hydroxyflunixin measured 12 h after the last administration of drug ranged from 1.56 to 40.6 ppb for all cows. Milk concentrations for 5-hydroxyflunixin were used to establish withdrawal periods of 36 h using guidelines established by the U.S. Food and Drug Administration/Center for Veterinary Medicine and 24 h using guidelines established by the European Medicinal Evaluation Agency/Committee on Veterinary Medicinal Products. 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Agric. Food Chem</addtitle><description>The objective of this study was to establish a withdrawal period for flunixin in milk by quantifying 5-hydroxyflunixin, the marker residue, in bovine milk as a function of time, following intravenous treatment of lactating dairy cows with flunixin-N-methyl glucamine (Banamine or Finadyne). Lactating dairy cows were dosed on three consecutive days at 2.2 mg of flunixin free acid/kg of body weight/day. Milk was collected twice daily and assayed using a liquid chromatography−mass spectrometry/mass spectrometry (LC-MS/MS) procedure. The method was validated at concentrations in the range 0.5−250 ppb. The concentrations for 5-hydroxyflunixin measured 12 h after the last administration of drug ranged from 1.56 to 40.6 ppb for all cows. Milk concentrations for 5-hydroxyflunixin were used to establish withdrawal periods of 36 h using guidelines established by the U.S. Food and Drug Administration/Center for Veterinary Medicine and 24 h using guidelines established by the European Medicinal Evaluation Agency/Committee on Veterinary Medicinal Products. Keywords: Flunixin meglumine; 5-Hydroxyflunixin; bovine milk; withdrawal period</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</subject><subject>body weight</subject><subject>Cattle - metabolism</subject><subject>Chromatography, Liquid</subject><subject>Clonixin - administration & dosage</subject><subject>Clonixin - analogs & derivatives</subject><subject>Clonixin - pharmacokinetics</subject><subject>dairy cows</subject><subject>Drug Residues - analysis</subject><subject>drugs</subject><subject>Female</subject><subject>Food and Drug Administration</subject><subject>guidelines</subject><subject>intravenous injection</subject><subject>Kinetics</subject><subject>Lactation</subject><subject>Mass Spectrometry</subject><subject>milk</subject><subject>Milk - chemistry</subject><subject>Time Factors</subject><subject>veterinary medicine</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpl0M9vFCEUB3BibOxaPfgPKIceTMwozC-GY1vdtumqtbPGI3kzQMuWhQ3MtN2j_3nZTNWDJwjvk_ceX4TeUPKRkpx-WmmS1znlH56hGa1yklWUNs_RjKRi1lQ13UcvY1wRQpqKkRdon5aMVA3nM_T7SkUjR4U_q41Vg_EOt8MotxicxL_McCMD3IPFlyoYL7H2Ac_t6MyDcdm3bK2Gm63Fp3bsYW2cwsbhY3-3u3019hbPvbX-3rhrfO6GAHfK-THiI5msielhN-8V2tNgo3r9dB6g5fzL8uQsW3w_PT85WmRQMDJkZc4Z62TNoWI91X3XkDrXsoROM8UoL3UBRDFVa9ZBLRlnHW84A2BNVdaqOEDvp7Z98DEGpcUmmDWEraBE7FIUf1JM9O1EN2O3VvIffEotgWwC6RPq4W8dwq2oWcEqsbxsRTtvLxY_rgpxnPy7yWvwAq6DieJnmxNaEkIL2vA8icNJQB_Fyo_BpSj-3-wRHMuS-Q</recordid><startdate>20030730</startdate><enddate>20030730</enddate><creator>Ngoh, Maureen A</creator><creator>Wislocki, Peter G</creator><creator>Thompson, Kenneth</creator><creator>Katz, Terry</creator><creator>Weingarten, Allan</creator><creator>TerHune, Terry</creator><creator>Hurshman, Bret</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20030730</creationdate><title>Residue Depletion Study and Withdrawal Period for Flunixin-N-methyl Glucamine in Bovine Milk Following Intravenous Administration</title><author>Ngoh, Maureen A ; Wislocki, Peter G ; Thompson, Kenneth ; Katz, Terry ; Weingarten, Allan ; TerHune, Terry ; Hurshman, Bret</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a370t-42977bd69a57c1fcb8062fd4abf7e7194f3a0e7e6f7ba6d797b9897aa78546e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</topic><topic>body weight</topic><topic>Cattle - metabolism</topic><topic>Chromatography, Liquid</topic><topic>Clonixin - administration & dosage</topic><topic>Clonixin - analogs & derivatives</topic><topic>Clonixin - pharmacokinetics</topic><topic>dairy cows</topic><topic>Drug Residues - analysis</topic><topic>drugs</topic><topic>Female</topic><topic>Food and Drug Administration</topic><topic>guidelines</topic><topic>intravenous injection</topic><topic>Kinetics</topic><topic>Lactation</topic><topic>Mass Spectrometry</topic><topic>milk</topic><topic>Milk - chemistry</topic><topic>Time Factors</topic><topic>veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ngoh, Maureen A</creatorcontrib><creatorcontrib>Wislocki, Peter G</creatorcontrib><creatorcontrib>Thompson, Kenneth</creatorcontrib><creatorcontrib>Katz, Terry</creatorcontrib><creatorcontrib>Weingarten, Allan</creatorcontrib><creatorcontrib>TerHune, Terry</creatorcontrib><creatorcontrib>Hurshman, Bret</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ngoh, Maureen A</au><au>Wislocki, Peter G</au><au>Thompson, Kenneth</au><au>Katz, Terry</au><au>Weingarten, Allan</au><au>TerHune, Terry</au><au>Hurshman, Bret</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Residue Depletion Study and Withdrawal Period for Flunixin-N-methyl Glucamine in Bovine Milk Following Intravenous Administration</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2003-07-30</date><risdate>2003</risdate><volume>51</volume><issue>16</issue><spage>4701</spage><epage>4707</epage><pages>4701-4707</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><abstract>The objective of this study was to establish a withdrawal period for flunixin in milk by quantifying 5-hydroxyflunixin, the marker residue, in bovine milk as a function of time, following intravenous treatment of lactating dairy cows with flunixin-N-methyl glucamine (Banamine or Finadyne). Lactating dairy cows were dosed on three consecutive days at 2.2 mg of flunixin free acid/kg of body weight/day. Milk was collected twice daily and assayed using a liquid chromatography−mass spectrometry/mass spectrometry (LC-MS/MS) procedure. The method was validated at concentrations in the range 0.5−250 ppb. The concentrations for 5-hydroxyflunixin measured 12 h after the last administration of drug ranged from 1.56 to 40.6 ppb for all cows. Milk concentrations for 5-hydroxyflunixin were used to establish withdrawal periods of 36 h using guidelines established by the U.S. Food and Drug Administration/Center for Veterinary Medicine and 24 h using guidelines established by the European Medicinal Evaluation Agency/Committee on Veterinary Medicinal Products. Keywords: Flunixin meglumine; 5-Hydroxyflunixin; bovine milk; withdrawal period</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>14705899</pmid><doi>10.1021/jf026219+</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of agricultural and food chemistry, 2003-07, Vol.51 (16), p.4701-4707 |
| issn | 0021-8561 1520-5118 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics body weight Cattle - metabolism Chromatography, Liquid Clonixin - administration & dosage Clonixin - analogs & derivatives Clonixin - pharmacokinetics dairy cows Drug Residues - analysis drugs Female Food and Drug Administration guidelines intravenous injection Kinetics Lactation Mass Spectrometry milk Milk - chemistry Time Factors veterinary medicine |
| title | Residue Depletion Study and Withdrawal Period for Flunixin-N-methyl Glucamine in Bovine Milk Following Intravenous Administration |
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