Metabolic Profiles of the Mycotoxin Zearalenone and of the Growth Promoter Zeranol in Urine, Liver, and Muscle of Heifers
A group of five heifers were fed for 84 days with 2 kg of zearalenone-contaminated oats (1370 μg/kg) resulting in an average daily intake of 2740 μg of zearalenone per animal. In a parallel experiment five heifers were implanted with two 25 mg zeranol pellets, one at the beginning of the study and o...
Gespeichert in:
Veröffentlicht in: | Journal of agricultural and food chemistry 2002-08, Vol.50 (17), p.4769-4776 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 4776 |
---|---|
container_issue | 17 |
container_start_page | 4769 |
container_title | Journal of agricultural and food chemistry |
container_volume | 50 |
creator | Kleinova, Martina Zöllner, Peter Kahlbacher, Hermann Hochsteiner, Werner Lindner, Wolfgang |
description | A group of five heifers were fed for 84 days with 2 kg of zearalenone-contaminated oats (1370 μg/kg) resulting in an average daily intake of 2740 μg of zearalenone per animal. In a parallel experiment five heifers were implanted with two 25 mg zeranol pellets, one at the beginning of the study and one after 42 days, and fed with 2 kg of “blank” control oats (79 μg/kg, daily intake = 158 μg). A third group of five animals were also fed with 2 kg of “blank” oats and served as control. Urine samples of all animals were collected every 5−6 days during the whole period of the study. Animals of all three groups were killed 84 days after the beginning of the feeding study. Tissue samples (back, femoral region, liver, and residues of implanted pellets) were taken during post-mortem investigations. The content of zearalenone and zeranol and their metabolites in urine and tissue samples was established by an analytical method combining solid-phase extraction and high-performance liquid chromatography−tandem mass spectrometry. Urinary excretion rates of zeralenone and zeranol were calculated from these results. Keywords: Zearalenone; zeranol; α-zearalanol; metabolism; heifer; cow; feeding study |
doi_str_mv | 10.1021/jf020160p |
format | Article |
fullrecord | <record><control><sourceid>acs_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1021_jf020160p</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>d049226587</sourcerecordid><originalsourceid>FETCH-LOGICAL-a445t-eccf04af6518c152b2cdf09eea9aacd2cfa83fbd64d96db322d606d610ee06413</originalsourceid><addsrcrecordid>eNpt0E1PGzEQBmCrKiqB9tA_UO2lByS22N61s3tEUD7UrIjUcOnFmrXHwmGzjuwNJf8ehwRy4eTDPO_I8xLyndFfjHJ2NreUUybp8hMZMcFpLhirPpMRTcO8EpIdkqMY55TSSozpF3LIOJOyFtWIrBscoPWd09k0eOs6jJm32fCAWbPWfvDPrs_-IQTosPc9ZtCbN3Ad_P_hYZNb-AFDYgF632UpcR9cj6fZxD1hOH3NNKuoO9xEb9BZDPErObDQRfy2e4_J_dXv2cVNPrm7vr04n-RQlmLIUWtLS7BSsEqn41qujaU1ItQA2nBtoSpsa2RpamnagnMjqTSSUUQqS1Yck5PtXh18jAGtWga3gLBWjKpNfeq9vmR_bO1y1S7Q7OWurwR-7gBEDZ1NB2sX966oSlEznly-dS4O-Pw-h_Co5LgYCzWb_lXyz3TWXFYT1ez3go5q7lehT5V88MEXsn-ULQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Metabolic Profiles of the Mycotoxin Zearalenone and of the Growth Promoter Zeranol in Urine, Liver, and Muscle of Heifers</title><source>ACS Publications</source><source>MEDLINE</source><creator>Kleinova, Martina ; Zöllner, Peter ; Kahlbacher, Hermann ; Hochsteiner, Werner ; Lindner, Wolfgang</creator><creatorcontrib>Kleinova, Martina ; Zöllner, Peter ; Kahlbacher, Hermann ; Hochsteiner, Werner ; Lindner, Wolfgang</creatorcontrib><description>A group of five heifers were fed for 84 days with 2 kg of zearalenone-contaminated oats (1370 μg/kg) resulting in an average daily intake of 2740 μg of zearalenone per animal. In a parallel experiment five heifers were implanted with two 25 mg zeranol pellets, one at the beginning of the study and one after 42 days, and fed with 2 kg of “blank” control oats (79 μg/kg, daily intake = 158 μg). A third group of five animals were also fed with 2 kg of “blank” oats and served as control. Urine samples of all animals were collected every 5−6 days during the whole period of the study. Animals of all three groups were killed 84 days after the beginning of the feeding study. Tissue samples (back, femoral region, liver, and residues of implanted pellets) were taken during post-mortem investigations. The content of zearalenone and zeranol and their metabolites in urine and tissue samples was established by an analytical method combining solid-phase extraction and high-performance liquid chromatography−tandem mass spectrometry. Urinary excretion rates of zeralenone and zeranol were calculated from these results. Keywords: Zearalenone; zeranol; α-zearalanol; metabolism; heifer; cow; feeding study</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf020160p</identifier><identifier>PMID: 12166958</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; Avena ; Biological and medical sciences ; Cattle - metabolism ; Chromatography, High Pressure Liquid ; Drug Implants ; Estrogens, Non-Steroidal - administration & dosage ; Estrogens, Non-Steroidal - pharmacokinetics ; Estrogens, Non-Steroidal - urine ; Female ; Food Contamination ; Food industries ; Fundamental and applied biological sciences. Psychology ; Liver - chemistry ; Liver - metabolism ; Mass Spectrometry ; Meat and meat product industries ; Muscle, Skeletal - chemistry ; Muscle, Skeletal - metabolism ; Zearalenone - administration & dosage ; Zearalenone - pharmacokinetics ; Zearalenone - urine ; Zeranol - administration & dosage ; Zeranol - pharmacokinetics ; Zeranol - urine</subject><ispartof>Journal of agricultural and food chemistry, 2002-08, Vol.50 (17), p.4769-4776</ispartof><rights>Copyright © 2002 American Chemical Society</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a445t-eccf04af6518c152b2cdf09eea9aacd2cfa83fbd64d96db322d606d610ee06413</citedby><cites>FETCH-LOGICAL-a445t-eccf04af6518c152b2cdf09eea9aacd2cfa83fbd64d96db322d606d610ee06413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf020160p$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf020160p$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13845912$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12166958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kleinova, Martina</creatorcontrib><creatorcontrib>Zöllner, Peter</creatorcontrib><creatorcontrib>Kahlbacher, Hermann</creatorcontrib><creatorcontrib>Hochsteiner, Werner</creatorcontrib><creatorcontrib>Lindner, Wolfgang</creatorcontrib><title>Metabolic Profiles of the Mycotoxin Zearalenone and of the Growth Promoter Zeranol in Urine, Liver, and Muscle of Heifers</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>A group of five heifers were fed for 84 days with 2 kg of zearalenone-contaminated oats (1370 μg/kg) resulting in an average daily intake of 2740 μg of zearalenone per animal. In a parallel experiment five heifers were implanted with two 25 mg zeranol pellets, one at the beginning of the study and one after 42 days, and fed with 2 kg of “blank” control oats (79 μg/kg, daily intake = 158 μg). A third group of five animals were also fed with 2 kg of “blank” oats and served as control. Urine samples of all animals were collected every 5−6 days during the whole period of the study. Animals of all three groups were killed 84 days after the beginning of the feeding study. Tissue samples (back, femoral region, liver, and residues of implanted pellets) were taken during post-mortem investigations. The content of zearalenone and zeranol and their metabolites in urine and tissue samples was established by an analytical method combining solid-phase extraction and high-performance liquid chromatography−tandem mass spectrometry. Urinary excretion rates of zeralenone and zeranol were calculated from these results. Keywords: Zearalenone; zeranol; α-zearalanol; metabolism; heifer; cow; feeding study</description><subject>Animals</subject><subject>Avena</subject><subject>Biological and medical sciences</subject><subject>Cattle - metabolism</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Drug Implants</subject><subject>Estrogens, Non-Steroidal - administration & dosage</subject><subject>Estrogens, Non-Steroidal - pharmacokinetics</subject><subject>Estrogens, Non-Steroidal - urine</subject><subject>Female</subject><subject>Food Contamination</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Liver - chemistry</subject><subject>Liver - metabolism</subject><subject>Mass Spectrometry</subject><subject>Meat and meat product industries</subject><subject>Muscle, Skeletal - chemistry</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Zearalenone - administration & dosage</subject><subject>Zearalenone - pharmacokinetics</subject><subject>Zearalenone - urine</subject><subject>Zeranol - administration & dosage</subject><subject>Zeranol - pharmacokinetics</subject><subject>Zeranol - urine</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E1PGzEQBmCrKiqB9tA_UO2lByS22N61s3tEUD7UrIjUcOnFmrXHwmGzjuwNJf8ehwRy4eTDPO_I8xLyndFfjHJ2NreUUybp8hMZMcFpLhirPpMRTcO8EpIdkqMY55TSSozpF3LIOJOyFtWIrBscoPWd09k0eOs6jJm32fCAWbPWfvDPrs_-IQTosPc9ZtCbN3Ad_P_hYZNb-AFDYgF632UpcR9cj6fZxD1hOH3NNKuoO9xEb9BZDPErObDQRfy2e4_J_dXv2cVNPrm7vr04n-RQlmLIUWtLS7BSsEqn41qujaU1ItQA2nBtoSpsa2RpamnagnMjqTSSUUQqS1Yck5PtXh18jAGtWga3gLBWjKpNfeq9vmR_bO1y1S7Q7OWurwR-7gBEDZ1NB2sX966oSlEznly-dS4O-Pw-h_Co5LgYCzWb_lXyz3TWXFYT1ez3go5q7lehT5V88MEXsn-ULQ</recordid><startdate>20020814</startdate><enddate>20020814</enddate><creator>Kleinova, Martina</creator><creator>Zöllner, Peter</creator><creator>Kahlbacher, Hermann</creator><creator>Hochsteiner, Werner</creator><creator>Lindner, Wolfgang</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20020814</creationdate><title>Metabolic Profiles of the Mycotoxin Zearalenone and of the Growth Promoter Zeranol in Urine, Liver, and Muscle of Heifers</title><author>Kleinova, Martina ; Zöllner, Peter ; Kahlbacher, Hermann ; Hochsteiner, Werner ; Lindner, Wolfgang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a445t-eccf04af6518c152b2cdf09eea9aacd2cfa83fbd64d96db322d606d610ee06413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Avena</topic><topic>Biological and medical sciences</topic><topic>Cattle - metabolism</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Drug Implants</topic><topic>Estrogens, Non-Steroidal - administration & dosage</topic><topic>Estrogens, Non-Steroidal - pharmacokinetics</topic><topic>Estrogens, Non-Steroidal - urine</topic><topic>Female</topic><topic>Food Contamination</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Liver - chemistry</topic><topic>Liver - metabolism</topic><topic>Mass Spectrometry</topic><topic>Meat and meat product industries</topic><topic>Muscle, Skeletal - chemistry</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Zearalenone - administration & dosage</topic><topic>Zearalenone - pharmacokinetics</topic><topic>Zearalenone - urine</topic><topic>Zeranol - administration & dosage</topic><topic>Zeranol - pharmacokinetics</topic><topic>Zeranol - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kleinova, Martina</creatorcontrib><creatorcontrib>Zöllner, Peter</creatorcontrib><creatorcontrib>Kahlbacher, Hermann</creatorcontrib><creatorcontrib>Hochsteiner, Werner</creatorcontrib><creatorcontrib>Lindner, Wolfgang</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kleinova, Martina</au><au>Zöllner, Peter</au><au>Kahlbacher, Hermann</au><au>Hochsteiner, Werner</au><au>Lindner, Wolfgang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic Profiles of the Mycotoxin Zearalenone and of the Growth Promoter Zeranol in Urine, Liver, and Muscle of Heifers</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2002-08-14</date><risdate>2002</risdate><volume>50</volume><issue>17</issue><spage>4769</spage><epage>4776</epage><pages>4769-4776</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>A group of five heifers were fed for 84 days with 2 kg of zearalenone-contaminated oats (1370 μg/kg) resulting in an average daily intake of 2740 μg of zearalenone per animal. In a parallel experiment five heifers were implanted with two 25 mg zeranol pellets, one at the beginning of the study and one after 42 days, and fed with 2 kg of “blank” control oats (79 μg/kg, daily intake = 158 μg). A third group of five animals were also fed with 2 kg of “blank” oats and served as control. Urine samples of all animals were collected every 5−6 days during the whole period of the study. Animals of all three groups were killed 84 days after the beginning of the feeding study. Tissue samples (back, femoral region, liver, and residues of implanted pellets) were taken during post-mortem investigations. The content of zearalenone and zeranol and their metabolites in urine and tissue samples was established by an analytical method combining solid-phase extraction and high-performance liquid chromatography−tandem mass spectrometry. Urinary excretion rates of zeralenone and zeranol were calculated from these results. Keywords: Zearalenone; zeranol; α-zearalanol; metabolism; heifer; cow; feeding study</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>12166958</pmid><doi>10.1021/jf020160p</doi><tpages>8</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0021-8561 |
ispartof | Journal of agricultural and food chemistry, 2002-08, Vol.50 (17), p.4769-4776 |
issn | 0021-8561 1520-5118 |
language | eng |
recordid | cdi_crossref_primary_10_1021_jf020160p |
source | ACS Publications; MEDLINE |
subjects | Animals Avena Biological and medical sciences Cattle - metabolism Chromatography, High Pressure Liquid Drug Implants Estrogens, Non-Steroidal - administration & dosage Estrogens, Non-Steroidal - pharmacokinetics Estrogens, Non-Steroidal - urine Female Food Contamination Food industries Fundamental and applied biological sciences. Psychology Liver - chemistry Liver - metabolism Mass Spectrometry Meat and meat product industries Muscle, Skeletal - chemistry Muscle, Skeletal - metabolism Zearalenone - administration & dosage Zearalenone - pharmacokinetics Zearalenone - urine Zeranol - administration & dosage Zeranol - pharmacokinetics Zeranol - urine |
title | Metabolic Profiles of the Mycotoxin Zearalenone and of the Growth Promoter Zeranol in Urine, Liver, and Muscle of Heifers |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T11%3A18%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-acs_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metabolic%20Profiles%20of%20the%20Mycotoxin%20Zearalenone%20and%20of%20the%20Growth%20Promoter%20Zeranol%20in%20Urine,%20Liver,%20and%20Muscle%20of%20Heifers&rft.jtitle=Journal%20of%20agricultural%20and%20food%20chemistry&rft.au=Kleinova,%20Martina&rft.date=2002-08-14&rft.volume=50&rft.issue=17&rft.spage=4769&rft.epage=4776&rft.pages=4769-4776&rft.issn=0021-8561&rft.eissn=1520-5118&rft.coden=JAFCAU&rft_id=info:doi/10.1021/jf020160p&rft_dat=%3Cacs_cross%3Ed049226587%3C/acs_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/12166958&rfr_iscdi=true |