Automated Strong Cation Exchange Extraction of Fatty Acid Esters of 3-(N-Phenylamino)-1,2-propanediol from Oil Samples for Routine Quantification by HPLC-APCI/MS/MS
Fatty acid esters of 3-(N-phenylamino)-1,2-propanediol are currently considered the best chemical markers of toxic oils related to the Spanish toxic oil syndrome. Recent research in this area has undertaken the exhaustive and quantitative characterization of these compounds in oils collected during...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2001-11, Vol.49 (11), p.5085-5091 |
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| container_issue | 11 |
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| container_title | Journal of agricultural and food chemistry |
| container_volume | 49 |
| creator | Calaf, Rosa E Peña, Juana Paytubi, Sonia Carrascal, Montserrat Posada, Manuel Gelpi, Emilio Abian, Joaquin |
| description | Fatty acid esters of 3-(N-phenylamino)-1,2-propanediol are currently considered the best chemical markers of toxic oils related to the Spanish toxic oil syndrome. Recent research in this area has undertaken the exhaustive and quantitative characterization of these compounds in oils collected during the epidemic outbreak. Current methods developed in this laboratory are based on solid phase extraction (SPE) using SCX cartridges followed by HPLC-APCI/MS/MS quantification. To circumvent the long and tedious extraction procedure, the SPE protocol was adapted for automatic extraction and the problems derived from the use of the immiscible solvents required for the SCX extraction were solved. Linearity of the analytical method was found in the same range as for the manual method. Extraction recoveries were 87 and 75% for 2-hydroxy-3-(N-phenylamino)propyl linoleate and 2-(linoleyloxy)-3-(N-phenylamino)propyl linoleate, respectively, and the corresponding coefficients of variation were ∼1%, greatly improving reproducibility over manual procedures. Keywords: Toxic oil syndrome; fatty acid esters of 3-(N-phenylamino)-1,2-propanediol; strong cation exchange; HPLC-APCI/MS/MS |
| doi_str_mv | 10.1021/jf0105541 |
| format | Article |
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Recent research in this area has undertaken the exhaustive and quantitative characterization of these compounds in oils collected during the epidemic outbreak. Current methods developed in this laboratory are based on solid phase extraction (SPE) using SCX cartridges followed by HPLC-APCI/MS/MS quantification. To circumvent the long and tedious extraction procedure, the SPE protocol was adapted for automatic extraction and the problems derived from the use of the immiscible solvents required for the SCX extraction were solved. Linearity of the analytical method was found in the same range as for the manual method. Extraction recoveries were 87 and 75% for 2-hydroxy-3-(N-phenylamino)propyl linoleate and 2-(linoleyloxy)-3-(N-phenylamino)propyl linoleate, respectively, and the corresponding coefficients of variation were ∼1%, greatly improving reproducibility over manual procedures. 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Agric. Food Chem</addtitle><description>Fatty acid esters of 3-(N-phenylamino)-1,2-propanediol are currently considered the best chemical markers of toxic oils related to the Spanish toxic oil syndrome. Recent research in this area has undertaken the exhaustive and quantitative characterization of these compounds in oils collected during the epidemic outbreak. Current methods developed in this laboratory are based on solid phase extraction (SPE) using SCX cartridges followed by HPLC-APCI/MS/MS quantification. To circumvent the long and tedious extraction procedure, the SPE protocol was adapted for automatic extraction and the problems derived from the use of the immiscible solvents required for the SCX extraction were solved. Linearity of the analytical method was found in the same range as for the manual method. Extraction recoveries were 87 and 75% for 2-hydroxy-3-(N-phenylamino)propyl linoleate and 2-(linoleyloxy)-3-(N-phenylamino)propyl linoleate, respectively, and the corresponding coefficients of variation were ∼1%, greatly improving reproducibility over manual procedures. Keywords: Toxic oil syndrome; fatty acid esters of 3-(N-phenylamino)-1,2-propanediol; strong cation exchange; HPLC-APCI/MS/MS</description><subject>Biological and medical sciences</subject><subject>Cation Exchange Resins</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Chromatography, Ion Exchange - methods</subject><subject>Fat industries</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Linoleic Acid - isolation & purification</subject><subject>Linoleic Acids</subject><subject>Mass Spectrometry - methods</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkN1q2zAUgMVYWbOuF3uBoZvBCtUqOZEsXQYv_RnZmtbdtZFlqVVmS0aSoXmfPWidJjQ3A8ER53ycnw-AzwR_JzgjF2uDCaZ0Rt6BCaEZRpQQ_h5M8FhEnDJyDD7GuMYYc5rjD-CYkJzMMs4m4N98SL6TSTewTMG7R1jIZL2Di2f1JN2jHj8pSPWa8wZeypQ2cK5sAxcx6RC3ySn69hutnrTbtLKzzp8hcp6hPvheOt1Y30ITfAdvbQtL2fWtjtD4AO_9kKzT8G6QLllj1W5yvYHXq2WB5qvi5uJXOb5P4MjINurTfTwBfy4XD8U1Wt5e3RTzJZLTXCTE82leK0NpQzFvhBA1E7rOG0bNTGiRaZZjpg2nghHOtWAMSyZoTalROZN4egLOdn1V8DEGbao-2E6GTUVwtTVdvZke2S87th_qTjcHcq92BL7uARmVbE2QTtl44GYEs4xuh6IdZ0efz291Gf5WbDyIVg-rslpe_WA_S3pX8UNfqWK19kNwo5L_LPgCccWfUw</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Calaf, Rosa E</creator><creator>Peña, Juana</creator><creator>Paytubi, Sonia</creator><creator>Carrascal, Montserrat</creator><creator>Posada, Manuel</creator><creator>Gelpi, Emilio</creator><creator>Abian, Joaquin</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20011101</creationdate><title>Automated Strong Cation Exchange Extraction of Fatty Acid Esters of 3-(N-Phenylamino)-1,2-propanediol from Oil Samples for Routine Quantification by HPLC-APCI/MS/MS</title><author>Calaf, Rosa E ; Peña, Juana ; Paytubi, Sonia ; Carrascal, Montserrat ; Posada, Manuel ; Gelpi, Emilio ; Abian, Joaquin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a379t-8737bcf55d508d999b69eb7d65f49e92e6706ef8596188e9660a695b55fc76a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Cation Exchange Resins</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Chromatography, Ion Exchange - methods</topic><topic>Fat industries</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Linoleic Acid - isolation & purification</topic><topic>Linoleic Acids</topic><topic>Mass Spectrometry - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calaf, Rosa E</creatorcontrib><creatorcontrib>Peña, Juana</creatorcontrib><creatorcontrib>Paytubi, Sonia</creatorcontrib><creatorcontrib>Carrascal, Montserrat</creatorcontrib><creatorcontrib>Posada, Manuel</creatorcontrib><creatorcontrib>Gelpi, Emilio</creatorcontrib><creatorcontrib>Abian, Joaquin</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calaf, Rosa E</au><au>Peña, Juana</au><au>Paytubi, Sonia</au><au>Carrascal, Montserrat</au><au>Posada, Manuel</au><au>Gelpi, Emilio</au><au>Abian, Joaquin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Automated Strong Cation Exchange Extraction of Fatty Acid Esters of 3-(N-Phenylamino)-1,2-propanediol from Oil Samples for Routine Quantification by HPLC-APCI/MS/MS</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>49</volume><issue>11</issue><spage>5085</spage><epage>5091</epage><pages>5085-5091</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>Fatty acid esters of 3-(N-phenylamino)-1,2-propanediol are currently considered the best chemical markers of toxic oils related to the Spanish toxic oil syndrome. Recent research in this area has undertaken the exhaustive and quantitative characterization of these compounds in oils collected during the epidemic outbreak. Current methods developed in this laboratory are based on solid phase extraction (SPE) using SCX cartridges followed by HPLC-APCI/MS/MS quantification. To circumvent the long and tedious extraction procedure, the SPE protocol was adapted for automatic extraction and the problems derived from the use of the immiscible solvents required for the SCX extraction were solved. Linearity of the analytical method was found in the same range as for the manual method. Extraction recoveries were 87 and 75% for 2-hydroxy-3-(N-phenylamino)propyl linoleate and 2-(linoleyloxy)-3-(N-phenylamino)propyl linoleate, respectively, and the corresponding coefficients of variation were ∼1%, greatly improving reproducibility over manual procedures. Keywords: Toxic oil syndrome; fatty acid esters of 3-(N-phenylamino)-1,2-propanediol; strong cation exchange; HPLC-APCI/MS/MS</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>11714286</pmid><doi>10.1021/jf0105541</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; ACS Publications |
| subjects | Biological and medical sciences Cation Exchange Resins Chromatography, High Pressure Liquid - methods Chromatography, Ion Exchange - methods Fat industries Food industries Fundamental and applied biological sciences. Psychology Linoleic Acid - isolation & purification Linoleic Acids Mass Spectrometry - methods |
| title | Automated Strong Cation Exchange Extraction of Fatty Acid Esters of 3-(N-Phenylamino)-1,2-propanediol from Oil Samples for Routine Quantification by HPLC-APCI/MS/MS |
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