1-(4-Ethynylphenyl)-4-substituted-2,6,7-trioxabicyclo[2.2.2]octanes: effect of 4-substituent on toxicity to houseflies and mice and potency at the GABA-gated chloride channel

1-(4-Ethynylphenyl)-2,6,7-trioxabicyclo[2.2.2]octanes with appropriate 4-substituents are among the most potent insecticides and GABA(A) receptor antagonists. Thirty-five analogues were prepared with varying 4-substituents comprising six n-alkyl, seven cycloalkyl, six branched alkyl, five alkenyl, e...

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