Antimutagenic Activity of Cacao: Inhibitory Effect of Cacao Liquor Polyphenols on the Mutagenic Action of Heterocyclic Amines
We investigated the effect of polyphenols derived from cacao liquor on the mutagenic action of heterocyclic amines (HCAs) in vitro and ex vivo. In the Ames test, the cacao liquor polyphenols showed antimutagenic effects in bacteria treated with HCA in the presence of an S-9 mixture; however, they sh...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2000-10, Vol.48 (10), p.5074-5078 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Yamagishi, Megumi Natsume, Midori Nagaki, Atsushi Adachi, Toko Osakabe, Naomi Takizawa, Toshio Kumon, Harue Osawa, Toshihiko |
| description | We investigated the effect of polyphenols derived from cacao liquor on the mutagenic action of heterocyclic amines (HCAs) in vitro and ex vivo. In the Ames test, the cacao liquor polyphenols showed antimutagenic effects in bacteria treated with HCA in the presence of an S-9 mixture; however, they showed less efficacy than quercetin. On the other hand, the cacao liquor polyphenols showed potent antimutagenic activity in bacteria treated with activated forms of HCA, compared with quercetin. We also evaluated the effect of these compounds on enzymatic activation of HCA. They weakly suppressed the production of activated HCA. In the host-mediated assay in mice, a method used to estimate the potential carcinogenicity of chemicals ex vivo, oral administration of the cacao liquor polyphenols, reduced the number of colonies of revertant bacteria recovered from the liver. These data suggest that the cacao liquor polyphenols have an antimutagenic effect not only in vitro, but also ex vivo. Keywords: Antimutagenicity; cacao liquor; polyphenol; Ames test; host-mediated assay; heterocyclic amines |
| doi_str_mv | 10.1021/jf000050n |
| format | Article |
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In the Ames test, the cacao liquor polyphenols showed antimutagenic effects in bacteria treated with HCA in the presence of an S-9 mixture; however, they showed less efficacy than quercetin. On the other hand, the cacao liquor polyphenols showed potent antimutagenic activity in bacteria treated with activated forms of HCA, compared with quercetin. We also evaluated the effect of these compounds on enzymatic activation of HCA. They weakly suppressed the production of activated HCA. In the host-mediated assay in mice, a method used to estimate the potential carcinogenicity of chemicals ex vivo, oral administration of the cacao liquor polyphenols, reduced the number of colonies of revertant bacteria recovered from the liver. These data suggest that the cacao liquor polyphenols have an antimutagenic effect not only in vitro, but also ex vivo. Keywords: Antimutagenicity; cacao liquor; polyphenol; Ames test; host-mediated assay; heterocyclic amines</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf000050n</identifier><identifier>PMID: 11052780</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; Antimutagenic Agents - chemistry ; Antimutagenic Agents - pharmacology ; Biological and medical sciences ; Cacao - chemistry ; Carcinogenesis, carcinogens and anticarcinogens ; Coffee, tea and other stimulative beverage industries ; Flavonoids ; Food industries ; Foods and miscellaneous ; Fundamental and applied biological sciences. Psychology ; Heterocyclic Compounds - antagonists & inhibitors ; Heterocyclic Compounds - toxicity ; In Vitro Techniques ; Medical sciences ; Mutagenicity Tests ; Mutagens - toxicity ; Phenols - chemistry ; Phenols - pharmacology ; Polymers - chemistry ; Polymers - pharmacology ; Polyphenols ; Rats ; Tumors</subject><ispartof>Journal of agricultural and food chemistry, 2000-10, Vol.48 (10), p.5074-5078</ispartof><rights>Copyright © 2000 American Chemical Society</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a443t-15fa2cf4f3950c5c95b993c0225bfb85ed3ba34a45263e2edc1590562c4e57143</citedby><cites>FETCH-LOGICAL-a443t-15fa2cf4f3950c5c95b993c0225bfb85ed3ba34a45263e2edc1590562c4e57143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf000050n$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf000050n$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27055,27903,27904,56716,56766</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=837995$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11052780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamagishi, Megumi</creatorcontrib><creatorcontrib>Natsume, Midori</creatorcontrib><creatorcontrib>Nagaki, Atsushi</creatorcontrib><creatorcontrib>Adachi, Toko</creatorcontrib><creatorcontrib>Osakabe, Naomi</creatorcontrib><creatorcontrib>Takizawa, Toshio</creatorcontrib><creatorcontrib>Kumon, Harue</creatorcontrib><creatorcontrib>Osawa, Toshihiko</creatorcontrib><title>Antimutagenic Activity of Cacao: Inhibitory Effect of Cacao Liquor Polyphenols on the Mutagenic Action of Heterocyclic Amines</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>We investigated the effect of polyphenols derived from cacao liquor on the mutagenic action of heterocyclic amines (HCAs) in vitro and ex vivo. In the Ames test, the cacao liquor polyphenols showed antimutagenic effects in bacteria treated with HCA in the presence of an S-9 mixture; however, they showed less efficacy than quercetin. On the other hand, the cacao liquor polyphenols showed potent antimutagenic activity in bacteria treated with activated forms of HCA, compared with quercetin. We also evaluated the effect of these compounds on enzymatic activation of HCA. They weakly suppressed the production of activated HCA. In the host-mediated assay in mice, a method used to estimate the potential carcinogenicity of chemicals ex vivo, oral administration of the cacao liquor polyphenols, reduced the number of colonies of revertant bacteria recovered from the liver. These data suggest that the cacao liquor polyphenols have an antimutagenic effect not only in vitro, but also ex vivo. Keywords: Antimutagenicity; cacao liquor; polyphenol; Ames test; host-mediated assay; heterocyclic amines</description><subject>Animals</subject><subject>Antimutagenic Agents - chemistry</subject><subject>Antimutagenic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cacao - chemistry</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Coffee, tea and other stimulative beverage industries</subject><subject>Flavonoids</subject><subject>Food industries</subject><subject>Foods and miscellaneous</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heterocyclic Compounds - antagonists & inhibitors</subject><subject>Heterocyclic Compounds - toxicity</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Mutagenicity Tests</subject><subject>Mutagens - toxicity</subject><subject>Phenols - chemistry</subject><subject>Phenols - pharmacology</subject><subject>Polymers - chemistry</subject><subject>Polymers - pharmacology</subject><subject>Polyphenols</subject><subject>Rats</subject><subject>Tumors</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0M1qGzEUBWBRUhon7aIvEAQhiywm0c9cz0x3xiRNwCGGpptuhEaWYrljyZHk0tllm9fsk0TGxiUQbQT3fLqIg9BXSi4oYfRyYUg-QNwHNKDASAGU1gdoQHJY1DCkh-goxkU2NVTkEzqklACrajJAzyOX7HKd5KN2VuGRSvaPTT32Bo-lkv7bv-cXfOvmtrXJhx5fGaNV2sd4Yp_WPuCp7_rVXDvfRewdTnON794szcP85kYnHbzqVbcZL63T8TP6aGQX9ZfdfYx-Xl89jG-Kyf332_FoUsiy5KmgYCRTpjS8AaJANdA2DVeEMWhNW4Oe8VbyUpbAhlwzPVMUGgJDpkoNFS35MTrf7lXBxxi0EatglzL0ghKxaVHsW8z2ZGtX63apZ__lrrYMTndARiU7E6RTNu5dzaumgayKrbIx6b_7VIbfYljxCsTD9IeoaX1X_YJK8OzPtl6qKBZ-HVwu5J3vvQKzwJXI</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Yamagishi, Megumi</creator><creator>Natsume, Midori</creator><creator>Nagaki, Atsushi</creator><creator>Adachi, Toko</creator><creator>Osakabe, Naomi</creator><creator>Takizawa, Toshio</creator><creator>Kumon, Harue</creator><creator>Osawa, Toshihiko</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20001001</creationdate><title>Antimutagenic Activity of Cacao: Inhibitory Effect of Cacao Liquor Polyphenols on the Mutagenic Action of Heterocyclic Amines</title><author>Yamagishi, Megumi ; Natsume, Midori ; Nagaki, Atsushi ; Adachi, Toko ; Osakabe, Naomi ; Takizawa, Toshio ; Kumon, Harue ; Osawa, Toshihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a443t-15fa2cf4f3950c5c95b993c0225bfb85ed3ba34a45263e2edc1590562c4e57143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Antimutagenic Agents - chemistry</topic><topic>Antimutagenic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cacao - chemistry</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Coffee, tea and other stimulative beverage industries</topic><topic>Flavonoids</topic><topic>Food industries</topic><topic>Foods and miscellaneous</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heterocyclic Compounds - antagonists & inhibitors</topic><topic>Heterocyclic Compounds - toxicity</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Mutagenicity Tests</topic><topic>Mutagens - toxicity</topic><topic>Phenols - chemistry</topic><topic>Phenols - pharmacology</topic><topic>Polymers - chemistry</topic><topic>Polymers - pharmacology</topic><topic>Polyphenols</topic><topic>Rats</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamagishi, Megumi</creatorcontrib><creatorcontrib>Natsume, Midori</creatorcontrib><creatorcontrib>Nagaki, Atsushi</creatorcontrib><creatorcontrib>Adachi, Toko</creatorcontrib><creatorcontrib>Osakabe, Naomi</creatorcontrib><creatorcontrib>Takizawa, Toshio</creatorcontrib><creatorcontrib>Kumon, Harue</creatorcontrib><creatorcontrib>Osawa, Toshihiko</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamagishi, Megumi</au><au>Natsume, Midori</au><au>Nagaki, Atsushi</au><au>Adachi, Toko</au><au>Osakabe, Naomi</au><au>Takizawa, Toshio</au><au>Kumon, Harue</au><au>Osawa, Toshihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimutagenic Activity of Cacao: Inhibitory Effect of Cacao Liquor Polyphenols on the Mutagenic Action of Heterocyclic Amines</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>48</volume><issue>10</issue><spage>5074</spage><epage>5078</epage><pages>5074-5078</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>We investigated the effect of polyphenols derived from cacao liquor on the mutagenic action of heterocyclic amines (HCAs) in vitro and ex vivo. In the Ames test, the cacao liquor polyphenols showed antimutagenic effects in bacteria treated with HCA in the presence of an S-9 mixture; however, they showed less efficacy than quercetin. On the other hand, the cacao liquor polyphenols showed potent antimutagenic activity in bacteria treated with activated forms of HCA, compared with quercetin. We also evaluated the effect of these compounds on enzymatic activation of HCA. They weakly suppressed the production of activated HCA. In the host-mediated assay in mice, a method used to estimate the potential carcinogenicity of chemicals ex vivo, oral administration of the cacao liquor polyphenols, reduced the number of colonies of revertant bacteria recovered from the liver. These data suggest that the cacao liquor polyphenols have an antimutagenic effect not only in vitro, but also ex vivo. Keywords: Antimutagenicity; cacao liquor; polyphenol; Ames test; host-mediated assay; heterocyclic amines</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>11052780</pmid><doi>10.1021/jf000050n</doi><tpages>5</tpages></addata></record> |
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| source | ACS Publications; MEDLINE |
| subjects | Animals Antimutagenic Agents - chemistry Antimutagenic Agents - pharmacology Biological and medical sciences Cacao - chemistry Carcinogenesis, carcinogens and anticarcinogens Coffee, tea and other stimulative beverage industries Flavonoids Food industries Foods and miscellaneous Fundamental and applied biological sciences. Psychology Heterocyclic Compounds - antagonists & inhibitors Heterocyclic Compounds - toxicity In Vitro Techniques Medical sciences Mutagenicity Tests Mutagens - toxicity Phenols - chemistry Phenols - pharmacology Polymers - chemistry Polymers - pharmacology Polyphenols Rats Tumors |
| title | Antimutagenic Activity of Cacao: Inhibitory Effect of Cacao Liquor Polyphenols on the Mutagenic Action of Heterocyclic Amines |
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