Collagen I Weakly Interacts with the β-Sheets of β 2 -Microglobulin and Enhances Conformational Exchange To Induce Amyloid Formation

Amyloidogenesis is significant in both protein function and pathology. Amyloid formation of folded, globular proteins is commonly initiated by partial or complete unfolding. However, how this unfolding event is triggered for proteins that are otherwise stable in their native environments is not well...

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Veröffentlicht in:	Journal of the American Chemical Society 2020-01, Vol.142 (3), p.1321-1331
Hauptverfasser:	Hoop, Cody L, Zhu, Jie, Bhattacharya, Shibani, Tobita, Caitlyn A, Radford, Sheena E, Baum, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - chemistry Amyloid - metabolism beta 2-Microglobulin - metabolism Collagen Type I - metabolism Humans Protein Binding Protein Conformation
Online-Zugang:	Volltext
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