Engineering a Catalytically Efficient Recombinant Protein Ligase

Breaking and forming peptidyl bonds are fundamental biochemical reactions in protein chemistry. Unlike proteases that are abundantly available, fast-acting ligases are rare. OaAEP1 is an enzyme isolated from the cyclotide-producing plant oldenlandia affinis that displayed weak peptide cyclase activi...

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Veröffentlicht in:	Journal of the American Chemical Society 2017-04, Vol.139 (15), p.5351-5358
Hauptverfasser:	Yang, Renliang, Wong, Yee Hwa, Nguyen, Giang K T, Tam, James P, Lescar, Julien, Wu, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Ligases - chemistry Ligases - isolation & purification Ligases - metabolism Models, Molecular Oldenlandia - enzymology Protein Engineering Recombinant Proteins - chemistry Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism
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