Quadruplex Folding Promotes the Condensation of Linker Histones and DNAs via Liquid–Liquid Phase Separation

Liquid–liquid phase separation (LLPS) of proteins and DNA has recently emerged as a possible mechanism underlying the dynamic organization of chromatin. We herein report the role of DNA quadruplex folding in liquid droplet formation via LLPS induced by interactions between DNA and linker histone H1...

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Veröffentlicht in:	Journal of the American Chemical Society 2021-07, Vol.143 (26), p.9849-9857
Hauptverfasser:	Mimura, Masahiro, Tomita, Shunsuke, Shinkai, Yoichi, Hosokai, Takuya, Kumeta, Hiroyuki, Saio, Tomohide, Shiraki, Kentaro, Kurita, Ryoji
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence DNA - chemistry G-Quadruplexes Heterochromatin - chemistry Histones - chemistry Liquid-Liquid Extraction Protein Binding Protein Domains
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