Glycoprotein Semisynthesis by Chemical Insertion of Glycosyl Asparagine Using a Bifunctional Thioacid-Mediated Strategy

Glycosylation is a major modification of secreted and cell surface proteins, and the resultant glycans show considerable heterogeneity in their structures. To understand the biological processes arising from each glycoform, the preparation of homogeneous glycoproteins is essential for extensive biol...

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Veröffentlicht in:Journal of the American Chemical Society 2021-07, Vol.143 (27), p.10157-10167
Hauptverfasser: Nomura, Kota, Maki, Yuta, Okamoto, Ryo, Satoh, Ayano, Kajihara, Yasuhiro
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Sprache:eng
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