Nuclear Resonance Vibrational Spectroscopic Definition of the Facial Triad Fe IV ═O Intermediate in Taurine Dioxygenase: Evaluation of Structural Contributions to Hydrogen Atom Abstraction

The α-ketoglutarate (αKG)-dependent oxygenases catalyze a diverse range of chemical reactions using a common high-spin Fe ═O intermediate that, in most reactions, abstract a hydrogen atom from the substrate. Previously, the Fe ═O intermediate in the αKG-dependent halogenase SyrB2 was characterized b...

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Veröffentlicht in:	Journal of the American Chemical Society 2020-11, Vol.142 (44), p.18886-18896
Hauptverfasser:	Srnec, Martin, Iyer, Shyam R, Dassama, Laura M K, Park, Kiyoung, Wong, Shaun D, Sutherlin, Kyle D, Yoda, Yoshitaka, Kobayashi, Yasuhiro, Kurokuzu, Masayuki, Saito, Makina, Seto, Makoto, Krebs, Carsten, Bollinger, Jr, J Martin, Solomon, Edward I
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Density Functional Theory Dioxygenases - chemistry Dioxygenases - metabolism Hydrogen - chemistry Hydrogen - metabolism Iron - chemistry Ketoglutaric Acids - chemistry Magnetic Resonance Spectroscopy Oxygen - chemistry
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