Recognition of a Single Guanine Bulge by 2-Acylamino-1,8-naphthyridine

2-Acylamino-1,8-naphthyridine (1), which possesses hydrogen bonding groups fully complementary to guanine (G), selectively binds to a single G bulge of duplex DNA. The melting temperature (T m) of the duplex containing a G bulge was increased by the presence of 1, whereas no increase of T m was obse...

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Veröffentlicht in:Journal of the American Chemical Society 2000-03, Vol.122 (10), p.2172-2177
Hauptverfasser: Nakatani, Kazuhiko, Sando, Shinsuke, Saito, Isao
Format: Artikel
Sprache:eng
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