A Catalytic Enantioselective Route to Hydroxy-Substituted Quaternary Carbon Centers:  Resolution of Tertiary Aldols with a Catalytic Antibody

Aldolase antibody 38C2-catalyzed resolutions of tertiary aldols were studied. Tertiary aldols proved to be very good substrates for antibody catalyzed retro-aldol reactions. The catalytic proficiency, (k cat/K M)/k uncat, of the antibody for these reactions was on the order of 1010 M-1. A fluorogeni...

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Veröffentlicht in:	Journal of the American Chemical Society 1999-08, Vol.121 (32), p.7283-7291
Hauptverfasser:	List, Benjamin, Shabat, Doron, Zhong, Guofu, Turner, James M, Li, Anthony, Bui, Tommy, Anderson, James, Lerner, Richard A, Barbas, Carlos F
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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